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A DIseAse MOdule Detection (DIAMOnD) algorithm derived from a systematic analysis of connectivity patterns of disease proteins in the human interactome.

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Academic year: 2017

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Fig 1. Topological properties of disease proteins within the Interactome. (A) Proteins associated with the same phenotype tend to localize in specific neighborhoods of the Interactome, indicating the approximate location of the corresponding disease module
Table 1. List of the 70 considered diseases. Disease #genes (LCC)  z-score  p-value Disease #genes(LCC)  z-score  p-value
Fig 2. The DIAMOnD algorithm. (A) At each step of the iterative algorithm, the connectivity significance of all immediate neighbors of disease proteins is calculated
Fig 3. Performance evaluation of DIAMOnD. We use two different methods to construct synthetic modules (shells and connectivity modules)
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