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Macrophages control tissue homeostasis via Ferritin heavy chain

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Academic year: 2021

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Figure  1.1.  Systematic  Fe  distribution  in  mammals.  Fe  homeostasis  involves  a  delicate  balance  between  the  Fe  levels  in  different  compartments
Figure 1.2 Intestinal Fe uptake. Simplified  scheme  illustrating  dietary  Fe  absorption  through the apical side of enterocytes in the  duodenum and the major players involved in  the transport of Fe to systemic circulation
Figure 1.3. Hepcidin regulates Fe homeostasis systemically. In response to excessive Fe levels and  inflammatory  cues  such  as  microbial  peptides,  IL-6,  activin  B  and  other  inflammatory  cytokines,  hepcidin production in the liver increases
Figure 1.4 IRP/IRE machinery controls intracellular Fe responses. In response to low iron levels,  IRP-1 and IRP-2 become activated and are able to bind to IRE sequences in the 5’ and 3’ end of FTH  and Transferrin Receptor (TfR) respectively which inhibit
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