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Modularity in protein complex and drug interactions reveals new polypharmacological properties.

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Academic year: 2017

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Figure 2. Bipartite network of protein complexes and drugs, and associated modules. A drug is connected to a protein complex if at least one protein target of the drug is also a subunit of the protein complex
Table 1. Top drug and complex hubs in the bipartite protein complex – drug network.
Figure 4. Projected network of drug modules. Each module of the protein complex – drug bipartite network was shrunk into a node and the drug projection of the resulting network is represented
Figure 5. Network metrics in projected networks of modules. Top panels are from the drug projection and bottom panels from the complex projection

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