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The role of brain derived neurotrophic factor (BDNF) on epilepsy

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Academic year: 2021

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Figure 1 – This image illustrates MFS which occurs in the hippocampus. Neurons with cellular bodies in the GCL bifurcate their axons in the hilar region of dentate gyrus, and project their collaterals o CA3 and to the ML.
Figure 2 - Seizures lead to a fast and slow increase in BDNF. The Fast increase is dependent on: i) NMDA receptors activation leading directly to BDNF release; ii) conversion of pro-BDNF to mature BDNF through tPA
Figure 3 – BDNF may increases seizures through TrkB receptor signaling pathway. TrkB activation diminish the abundance of the α1 subunit of GABA and increases the abundance of α4 subunit in GABA receptors Adapted from (Grabenstatter et al., 2012)
Table 1 - Studies suggesting that BDNF modulation inhibits epileptogenesis.
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