Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

(B) The selection function for the amino acid variants in nDNA and mtDNA encoded proteins, defined by dividing the observed distributions of pathogenicity scores by the distribution

Este conceito é desenvolvido por Luce Irigaray em This Sex Which is not one (1985), no qual, Irigaray atenta para o modo redutor de ver o feminino como uma mera reflexão daquilo

A maioria dos entrevistados considera que este tipo de comportamento se manifes- ta através da hiperbolização da informação apresentada ao nível do cargo/ função [E3: (…)

The external footprinting process of intelligence gathering stage comprises collecting answers from the objective target created from an exterior point of view..

In the 31 families investigated by direct sequencing (Table S1), three grandmothers from families 21, 27 and 30 (3/31 families, 9.7%) had homoplasmic point mutations that were

In addition to the mutations that underlie most cases of the multiple endocrine neoplasia type 1 (MEN1) syndrome, somatic mutations of the MEN1 gene have also been described

The aim of this study is to present the prevalence of mitochondrial DNA (mtDNA) mutations in cases with clinical symptoms and neuroimaging findings compatible with the diagnosis of

The aim of the present study is to investigate the prevalence of 10 pre- viously described mtDNA mutations in a type 2 diabe- tic group from Southern Brazil, and also search for new