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Genetic susceptibility to thyroid cancer : contributions of RET polymorphisms

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Academic year: 2021

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Figure 1 – Frontal view of the thyroid gland. The thyroid gland is located in the anterior neck in front  of  the  trachea, and  immediately  below  the  larynx,  it  has  a  butterfly-shape  and  is  constituted  by  two  lobes joined together by an isthm
Figure  3  -  Schematic  representation  of  the  RET  receptor  tyrosine  kinase.  The  extracellular  domain  includes  four  cadherin  domains  and  a  cysteine  rich  domain
Figure 4 - Different mechanisms of ligand-mediated RET activation. A: cis RET activation  model, the  GFL binds to GFRα anchored on a lipid platform, this complex will promote the dimerization of RET and  allowing the phosphorylation of the intracellular t
Table 2 - Primers and PCR conditions for amplification of gene RET exons 11, 13, 14 and 15
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