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Activation of the alternative NFκB pathway improves disease symptoms in a model of Sjogren's syndrome.

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Academic year: 2017

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Figure 1. BL-7040 is a TLR9 agonist. A. Luciferase reporter quantification of NFkB activation in HEK-293 cell lines stably expressing specific TLR proteins and treated with the established agonists and  BL-7040
Figure 3. Low dose BL-7040 activates the alternative TLR9 pathway in mouse mononuclear cells
Figure 6. Sjogren’s disease biopsies show elevated inflamma- inflamma-tory markers and suppressed alternative NF k B markers

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