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C/EBPβ-LAP*/LAP Expression Is Mediated by RSK/eIF4B-Dependent Signalling and Boosted by Increased Protein Stability in Models of Monocytic Differentiation.

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Academic year: 2017

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Fig 1. Dramatic increase in C/EBPβ-LAP * /LAP proteins and LAP/LIP ratio in different models of monocytic differentiation
Fig 2. Modest and retarded increase in C/EBPβ mRNA under differentiation-inducing conditions
Fig 4. Phosphorylated eIF4B is required for enhanced C/EBPβ-LAP*/LAP expression. (A) THP-1 monocytic cells were incubated for 24 h ± PMA, and the amounts of (p-)eIF4B were detected (n = 3)
Fig 5. PKR inhibition prevents C/EBPβ and eIF4B expression. (A) THP-1 cells were incubated with PMA ± 1 μM PKR inhibitor (PKR-I) up to 24 h, and the levels of LAP * /LAP were determined (n = 3)
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