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Design and synthesis of small molecule modulators of p53

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Academic year: 2021

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Figure 1.2. Cellular regulation of p53 by MDM2 (adapted from  [39]).
Figure 1.4. Nutlins optimization to RG7112. Right upper quadrant: crystal structure of compound 3 bound to  MDM2 (PDB 4IPF)
Figure  1.6.  Spiropyrrolidines  optimization  to  MI-106.  Docking  pose  of  compound  13  in  MDM2  (PDB  3LBL)
Figure 1.7. Spiropyrrolidines and others spiro-heterocyclic-oxindole derivatives.
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