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MicroRNA-7 inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via targeting FAK expression.

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Academic year: 2017

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Figure 1. miR-7 expression is decreased in breast cancer and is associated with tumor metastasis
Figure 2. miR-7 decreases FAK expression by directly targeting its 3 9 -UTR. (A) The potential binding sequences for miR-7 within the FAK 3 9 - -UTR of human (H.s), chimpanzee (P.t), mouse (M.m), guinea pig (C.p), rabbit (O.c), rat (R.n), and dog (C.f)
Figure 3. miR-7 promotes an epithelial phenotype in breast cancer cells. (A) Morphology of MDA-MB-435s and MDA-MB-231 cells transiently transfected with mature miR-7 or the control miRNA
Figure 5. miR-7 inhibits breast cancer cell tumorigenesis in vitro . (A) miR-7 decreases MDA-MB-435s and MDA-MB-231 cell proliferation in vitro and inhibition of endogenous miR-7 expression promotes HBL-100 cell monolayer proliferation
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