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Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages.

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Academic year: 2017

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Figure 2. Small molecule R243 inhibits CCR8 signaling and chemotaxis. (A) Structure of R243
Figure 3. R243 inhibited LPS-induced cytokine production by mouse PMQ. (A) PMQ or (B) BMMQ were collected from naı¨ve WT or CCR8 -/- -/-mice
Figure 5. CCR8 ligand secretion was not required for LPS- LPS-induced IL-10 secretion
Figure 7. CCR8 deficiency and R243 attenuated postoperative peritoneal adhesions and acute colitis in vivo

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