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Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis.

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Academic year: 2017

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Figure 1. pen/lgl2 deficient epidermal cells form tumors in a cell autonomous fashion
Figure 2. Epidermal cells undergo EMT in pen/lgl2 mutant larvae. Basal epidermal cells of wild type and pen/lgl2 mutant 5dpf stained using pan 1–8 Cytokeratin antibody (Ai - Bii) and E-cad antibody (C, D)
Figure 3. pen/lgl2 mutant epidermal cells differentially express EMT regulators. Graphical representation of expression data of some of the relevant genes obtained by microarray (A) and quantitative RT-PCR (B)
Figure 4. Inhibition of ErbB signaling restores the epidermal morphology and cell cycle in pen/lgl2 mutant larvae
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