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Construction and analysis of the protein-protein interaction networks based on gene expression profiles of Parkinson's disease.

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Academic year: 2017

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Figure 1 gives the flowchart of research methodology applied in this study. The raw data (CEL files) of microarray data series GSE8397 were downloaded from Gene Expression Omnibus (GEO) (http://www.ncbi.nlm.nih.gov/geo/) and normalized by gcRMA [9]
Table 2. Global properties of the networks.
Table 4. Number of obtained hubs (HC nodes) & bottlenecks (HBLC nodes). GeneChip A (HG_133A) Number of hubs (HC nodes) Number of bottlenecks(HBLC nodes) N A 2ttt 19 41 N A SAM 5 14 GeneChip B (HG_133B) N B 2ttt 5 7 doi:10.1371/journal.pone.0103047.t004
Table 7. Hubs & bottlenecks in N 2ttt B .
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