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Braz. J. Pharm. Sci. vol.47 número2

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Academic year: 2018

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FIGURE 1  - Spectra and chemical structures of antineoplastic drugs:  (A) luorouracil, (B) ifosfamide, (C) doxorubicin and (D)  cyclophosphamide.
TABLE I  - System suitability parameters* for HPLC-UV method evaluated for simultaneous determination of luorouracil, ifosfamide,  cyclophosphamide and doxorubicin
FIGURE 2  - Results expressed as extraction eficiency (%) of luorouracil (5-FU), ifosfamide (IF), cyclophosphamide (CP) and  doxorubicin (DOX), in the LLE studies of type (A) and solvent extractor volume (B), shaking velocity (C) and number of extractions
TABLE II  - Analytical curve parameters for simultaneous determination of luorouracil (5-FU), ifosfamide (IF), doxorubicin (DOX)  and cyclophosphamide (CP) by HPLC-DAD-UV
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