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Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock

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Academic year: 2021

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Figure 1: Segmentation of the chick embryo. Schematic representa- representa-tion of two distinct development stages of the chick embryo (dorsal view, 4HH and 9HH [2])
Figure 2: The molecular clock and wavefront. (a) Representation of the segmentation clock, visualized as distinct phases of expression (I, II, and III) of the chick oscillating gene hairy1 [32]
Table 1: Genes belonging to the signalling pathways Notch, Wnt, or Fgf shown to have an oscillatory behaviour in mouse, chick, and zebrafish embryos.
Table 2: Mutations in key genes belonging to the Notch, Wnt, and Fgf signaling pathways and subsequent phenotype observed in the expression of genes involved either in the molecular clock or in the wavefront of differentiation
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