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Novel transcriptional regulation mechanisms associated with Parkinson’s disease pathogenesis: from biological activity towards therapy

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Academic year: 2021

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Figure 2 - Molecular and intracellular effects caused by dopaminergic toxins. Once inside the brain,  1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (MPTP,  black  vesicles)  is  taken  up  by  astrocytes  and  is  converted  in  1-methyl-4-phenylpyridinium
Figure 3 - Mechanisms of acetylation and deacetylation. The HAT and HDACs mediate the acetylation  and  deacetylation,  respectively
Figure 4 - CtBP1 and CtBP2 protein structures.  CtBPs are composed by a PXDLS-binding cleft, a RRT- RRT-binding  cleft,  and  the  dehydrogenase  domain
Figure  8  - Expression  levels  and  cellular  localization  of  CtBPs  in  the  ST  and  SN  of  adult  mice
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