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Functional and evolutionary significance of human microRNA seed region mutations.

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Academic year: 2017

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Fig. 1. A single nucleotide difference in seed region of miRNAs is associated with a major change in regulated target genes
Fig. 2. Sequence alignments of miR-429, miR-200b, miR-141, miR-205, M12, M14 and M5. Seed and non- non-seed regions are colored in red and blue, respectively
Fig. 3. Overlap among differentially expressed (DE) genes in HEY cells after ectopic expression of miRNAs with different seed region sequences.
Fig. 4. The high functional cost of even single nucleotide changes in miRNA seed regions implies a mechanism of miRNA regulatory evolution
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