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Three novel downstream promoter elements regulate MHC class I promoter activity in mammalian cells.

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Academic year: 2017

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Figure 1. Three downstream sequences are conserved among MHC class I promoters. The sequences +4 to +8 and +12 to +16 and +27/28 to +31/32 of the swine SLA class I gene, PD1, and the human HLA class genes, HLA-A, HLA-B and HLA-C were aligned
Figure 2. Three downstream elements reside in the downstream region of the MHC class I promoter
Figure 3. DPE-L1 and DPE-L2 functions are not additive. A) Schematic illustration of DPE-L1, DPE-L2, GLE, DPE-L1/2 and GLE/DPE- GLE/DPE-L1/2 mutants
Figure 5. Downstream elements preferentially regulate upstream transcription start sites in constitutive transcription.
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