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Ago-2-mediated slicer activity is essential for anti-flaviviral efficacy of RNAi.

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Academic year: 2017

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Table 1. Sequence of siRNA and miRNA mimicking oligonucleotides.
Figure 1. All 4 Ago proteins bind both fully complementary siRNA and partially complementary miRNA resembling oligos and repress target gene in reporter assays
Figure 2. Only Ago-2 bound fully complementary siRNA shows antiviral activity. A, B) ES cells expressing individual Ago proteins were transfected with fully or partially complementary siRNAs, infected with dengue virus (A) or WNV (B) and virus replication

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