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Uveal melanoma cells utilize a novel route for transendothelial migration.

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Academic year: 2017

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Fig. 1. UM cells transmigrate through a novel intercalation process. A) Frames from DIC movies of UM cells, 92.1 and OCM-1A, intercalating into the endothelial monolayer (S1 Movie)
Fig. 2. Invasive projections are rich in F-actin. Frames from S2 Movie show a UM cell (OCM-1A) with F- F-tractin-labeled actin filaments intercalating between ECs in a monolayer
Fig. 3. Melanoma transmigration is a stepwise process. A) Frames from S3 Movie showing transmigration of a UM cell (OCM-1A) expressing F-tractin (pseudocolored to show fluorescence intensity)
Fig. 4. Localization of VCAM and VE-cadherin in UM cells interacting with ECs. Cell preparations were fixed and stained at indicated times after addition of UM cells
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