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[PENDING] Development of a binding assay between the HIV-1 envelope protein (gp120) and coreceptors CCR5/CXCR4 by Surface Plasmon Resonance : Screening and optimization of viral entry inhibitors

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Academic year: 2024

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Figure 1.1Diagrammatic representation of the global prevalence of HIV infected adults and children living with HIV at the end of 2009 (UNAIDS 2011)
Figure 1.2 Early after primary infection there is widespread dissemination of virus and a sharp decrease in CD4 + T cells count in peripheral blood
Figure 1.3 HIV structure and genome organisation: the 9 viral genes are depicted (9.7 kb) which encode open reading frames for at least 16 structural, regulatory, accessory and enzymatic proteins
Figure 1.4 Model of gp120 trimer from the orientation of the viral membrane. The gp120 core is a copper brown and carbohydrate core structures are blue
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