A2A receptors
Characterization of the levels and G-protein coupling of adenosine A2A receptors in hippocampus and striatum of transgenic rats overexpressing adenosine A2A receptors in the brain
... in transgenic rats overexpressing human adenosine A2A receptors in the brain. Neurobiol Learn Mem 2007;87:42-56. 15. Laurent C, Burnouf S, Ferry B, et al. A2A adenosine receptor deletion is ...
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Adenosine A2A receptors in the rat hippocampus: stress related changes
... More importantly, the animals were not tested right after the stress induction period, from PND2 until PND 14, where the effects could still be attributed to acute effects in the HPA- axis and hence reversible. Rather, ...
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Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation
... The striatum is the main input and information processing struc- ture of the basal ganglia. Cortico-limbic-thalamic glutamatergic and mesencephalic dopaminergic systems converge in the GABAergic medium-sized spiny ...
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Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts : implications for neuromodulation
... tion after a short (5 min) incubation time with BDNF. Treatment with BDNF (20 ng/ml) for 5 min did not significantly change TrkB localization but induced the phosphorylation of TrkB re- ceptors in the lipid raft fraction ...
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Aging pathology in sprague dawley rats : background lesions and comparative study between wild type and transgenic rats with neuronal overexpression of human adenosine A2A receptors
... hippocampus, transgenic SD rats that overexpress human A2AR driven by the CaMKIIα promoter have been generated by Coelho and colleagues (Tg (CaMKII-hA2AR)). Calcium/Calmodulin-activated protein kinase IIα (CaMKIIα) was ...
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Hydrogen sulfide inhibits A2A adenosine receptor agonist induced β-amyloid production in SH-SY5Y neuroblastoma cells via a cAMP dependent pathway.
... A1A receptors is important in controlling the early events in case of brain damage, blocking of A2A receptors seems to be more important in context of the latter ...A1A receptors decreases as ...
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Caffeine effects on 6OHDAlesioned rats are mediated by seal factors, including proinflammatory cytokines and histone deacetylase inhibitions
... Tyrosine hydroxylase is the rate limiting step, in catecholamine synthesis, and the reduced TH expression observed in PD leads to a reduced DA synthesis in the striatum [33]. Thus, PD may be consid- ered as a syndrome of ...
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Myocardial chemokine expression and intensity of myocarditis in Chagas cardiomyopathy are controlled by polymorphisms in CXCL9 and CXCL10.
... T cells producing IFN-c and/or TNF-a were found in PBMC from CCC patients, as compared with ASY patients [26]. Previous studies from our group showed that gene expression levels of IFN-c-inducible chemokines CXCL9 and ...
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Rev. Bras. . vol.74 número4 en a02v74n4
... progesterone receptors on vocal fold epithelium in 19 vocal fold epithelium specimens that did not present any indication of disease, especially inflammatory ...progesterone receptors in 18 of the 19 ...
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Adipocyte dysfunction in a mouse model of polycystic ovary syndrome (PCOS): evidence of adipocyte hypertrophy and tissue-specific inflammation.
... The relevance of current animal models of PCOS that involve the administration of androgens or other steroid hormones to the etiology of PCOS in humans is uncertain [32,33]. We have recently shown that specific genetic ...
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Tissue responsiveness to estradiol and genistein in the sea bass liver and scale
... presence of other molecular determinants of estrogen cellular actions, namely co-regulators or other transcription factors, and the cross-talk between different cell types and signaling systems (Pinto et al. 2014). ...
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Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation.
... P2Y receptors [25,47], whereas the late sustained phosphorylation is also mediated by MMP-2 ...putative receptors, ErbB2 and ErbB3, are known to be induced in injured sciatic nerves in rats, promoting ...
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Exercício físico, receptores β-adrenérgicos e resposta vascular
... induces vasoconstriction by activating α-adrenergic recep- tors present within vascular smooth muscle cells, whereas acetylcholine promotes vasodilation by activating mus- carinic receptors present within ...
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Chemokines, lymphocytes, and HIV
... their receptors are ...chemokine receptors can be activated by more than one chemokine ...chemokine receptors, with T cell line-tropic strains using CXCR4 and macro- phage-tropic strains using CCR5 ...
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Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic
... In accordance with our results, are the results of Boulanger and Poo (1999a) at developing neuromuscular synapses showing that presynaptic depolarization is a critical factor in causing the synaptic action of ...
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How signaling receptors meet their end.
... What is the role of Hrs? Since Hrs depletion seems to get in the way of SNX3 doing its job, but SNX3 knockdown doesn’t block receptor transport and degradation, it appears that Hrs is responsible for transporting the ...
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Role of somatostatin receptors in angiogenesis
... The relative expressions of SSTR 5 obtained for all samples in comparison with HPRT expression are residual (Figure 35). Adams et al (2005) described in their results that 3 of 9 (33,3%) different primary HUVEC (from ...
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Diffusion barriers constrain receptors at synapses.
... ses: 11.4662.40 s; t test p = 0.04, excitatory synapses: 9.8761.36 s, t test p = 0.008; Fig. 4D), suggesting increased diffusion constraints for SEP-c2 at both excitatory and inhibitory synapses. The significant ...
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Regulation of human umbilical artery contractility by different serotonin and histamine receptors
... + 64.6 mg). However, we also observed that L69 did not induce the same contractile effect in all the HUA rings. As shown in the Figure 2, there are 3 bars to represent the effect of this agonist. The second bar ...
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Comparative analysis of calcium spikes upon activation of serotonin(1A) and purinergic receptors.
... GPCRs mediate multiple physiological processes such as neurotransmission, cellular metabolism, secretion, cellular growth and differentiation, and immune response [27]. However, only a limited number of second ...
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