α-synuclein
Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice.
... wild-type α-synuclein (Syn-GFP), which mimics duplication and triplication mutations found in some human patients ...behavior, α- synuclein phosphorylation, and aggregation in these ...
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New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease.
... and α-synuclein fibrils ...and α-synuclein, were de- graded afterwards in the late endosomes ...and α-synuclein accumula- tion could be regulated by ...intracellular α ...
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α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity.
... Parkinson disease (PD) is the most common movement disorder, currently affecting approximately 2% of the population older than age 60 years. Hallmarks of PD are the loss of dopaminergic neurons in the substantia nigra ...
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Olfactory dysfunction and neurotransmitter disturbance in olfactory bulb of transgenic mice expressing human A53T mutant α-synuclein.
... It is known that α-synuclein (αSyn) is the main composition of LBs [13]. Various point mu- tations (A53T, A30P and E46K) in the gene coding αSyn have been found to result in domi- nant familial PD ...
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Multifunctional drugs: monoamine oxidase and α-synuclein as targets for the treatment of Parkinson's disease.
... AND α-SYNUCLEIN AS TARGETS FOR THE TREATMENT OF PARKINSON´S ...and α-synuclein ...in α-synuclein ...notably α-synuclein fibrillation and dopamine metabolism, ...
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Hypericum perforatum phenolic compounds : protective role in the toxicity induced by heterologous expression of α-synuclein and huntingtin in yeast cells
... of α-synuclein A30P mutant form was also expected, since the A30P mutation reduces the affinity of the protein to interact with phospholipids, a pre-requisite to aggregation (Auluck et ...WT ...
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α-synuclein reactive antibodies as diagnostic biomarkers in blood sera of Parkinson's disease patients.
... a-synuclein is relatively abundant in the brain under non- pathological conditions. It is a natively unfolded protein present mostly in the cytosol. It plays an essential role in synaptic transmission and synaptic ...
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Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy.
... Neurosin levels in CSF from AD patients and controls have previously been investigated in two different studies. These two studies employed different ELISA assays [33,35] and presented conflicting results. The first ...
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Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease.
... Tauopathic pathways lead to degenerative changes in Alzheimer’s disease and there is evidence that they are also involved in the neurodegenerative pathology of Parkinson’s disease [PD]. We have examined tauopathic ...
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Using gastrocnemius sEMG and plasma α-synuclein for the prediction of freezing of gait in Parkinson's disease patients.
... Freezing of gait (FOG) is a complicated gait disturbance in Parkinson’s disease (PD) and a relevant subclinical predictor algorithm is lacking. The main purpose of this study is to explore the potential value of surface ...
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Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies.
... The sequence of the three synuclein protein is highly conserved, especially within their N terminal domains. When the sequences of a-syn and b-syn are compared, a major difference within the hydrophobic central ...
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Assessment of α-synuclein secretion in mouse and human brain parenchyma.
... subjected to microdialysis. The levels of a-synuclein in mouse plasma (,3 ng/ml) were at least 6-fold higher than those found in mouse ISF. Importantly, we found that a-synuclein levels in ISF remained ...
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Structural and dynamical insights into the membrane-bound α-synuclein.
... Figure 5 shows the plot of all four fluorescence readouts (spectral shift, quenching efficiency, anisotropy and REES) of a- synuclein in the presence of SUVs prepared using negatively charged lipids namely POPA, ...
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Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies.
... Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by striatonigral degeneration and olivo-pontocerebellar atrophy. The histopathological hallmark of MSA is glial cytoplasmic ...
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Human α4β2 nicotinic acetylcholine receptor as a novel target of oligomeric α-synuclein.
... Cigarette smoking is associated with a decreased incidence of Parkinson disease (PD) through unknown mechanisms. Interestingly, a decrease in the numbers of a4b2 nicotinic acetylcholine receptors (a4b2-nAChRs) in PD ...
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A label-free immunosensor for electrochemical determination of alpha-synuclein
... of α-syn remains not yet defined [25], but several works have investigated its role in neurodegenerative diseases including ...release α-syn into their conditioned culture medium, and that α-syn can ...
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ISSN 0100-879X BIOMEDICAL SCIENCES AND CLINICAL INVESTIGATION
... aberrant α-synuclein degrada- tion is observed in the disease ...in α-synuclein are substrates of autophagy, and the clearance of these mutant forms will be retarded if the autophagic process ...
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Using induced pluripotent stem cells to investigate the mechanistic link between Gaucher disease and Parkinson related synucleinopathies
... analyze α-synuclein ...matched α-synuclein ...change α-synuclein ...and α-synuclein, that is, β-glucocerebrosidase deficiency leading to lysosomal disfunction and ...
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J. Braz. Chem. Soc. vol.18 número2
... now describe the isolation and characterization of two new diterpenes abietanes derivatives, 3 β -hydroxy-9 α , 13 α - epidioxyabiet-8(14)-ene ( 1 ) and 3-oxo-9 α , 13 α - epidioxyabiet[r] ...
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Teoria Cº vetorial em geometria riemanniana e decomposição em bolhas para aplicações de Palais-Smale
... para toda vizinhan¸ca de V de x. O estudo dos pontos de concentra¸c˜ao, em teoria de blow-up, ´e tratado no caso k = 1 e p = 2 em [DHR] e em [He1] no caso k ≥ 1 e p = 2. Na ´otica de extremais a concentra¸c˜ao aparece ...
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