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Amyloid β (Aβ)

Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy.

Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy.

... cellular amyloid plaques [3, 4]. Amyloid-β (Aβ), the major component of these amyloid plaques, is produced by cleavage of the amyloid precursor protein through β- and ...

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Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype.

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype.

... the amyloid precursor protein (APP) or presenilin (PS) 1 or PS2 give rise to early onset, familial AD ...of amyloid-β (Aβ) which is derived from the proteolytic processing of APP [5], along with ...

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Amyloid-β peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex

Amyloid-β peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex

... received amyloid-β or ...performed. Amyloid-β did not change the kinases activity in the hippocampus and cerebral cortex of ...by amyloid-β, but for the cytosolic fraction, it ...

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Amyloid β peptide and p63 : two prime triggers of neural apoptosis and differentiation

Amyloid β peptide and p63 : two prime triggers of neural apoptosis and differentiation

... péptido β amilóide (Aβ) na AD foi desde cedo reportada como sendo um aspeto crucial nos fenómenos patológicos da doença, nomeadamente na formação de placas ...

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Brain-derived neurotrophic factor and adenosine signalling on amyloid-β peptide induced toxicity : impact on hippocampal function

Brain-derived neurotrophic factor and adenosine signalling on amyloid-β peptide induced toxicity : impact on hippocampal function

... this single fragment was able to recapitulate many hallmarks of AD, such as progressive neuronal loss in cortex and hippocampus, forebrain atrophy, tau pathology, amyloid plaques, intraneuronal Aβ accumulation, ...

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Apoptosis signaling associated with amyloid β-induced cellular dysfunction and degeneration : relevance for Alzheimer’s disease

Apoptosis signaling associated with amyloid β-induced cellular dysfunction and degeneration : relevance for Alzheimer’s disease

... Aggregation/fibrillization of Aβ plays a critical role in neurodegeneration. It is now considered that the transition from soluble monomeric species circulating under normal conditions to the oligomeric, protofibrillar ...

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Cognition and memory function of Taraxacum coreanum in an in vivo amyloid-β-induced mouse model of Alzheimer’s disease

Cognition and memory function of Taraxacum coreanum in an in vivo amyloid-β-induced mouse model of Alzheimer’s disease

... AD is the most common cause of progressive cogni- tive decline and dementia in aged humans (Meziane et al., 1998). Although the causes of AD are not well known, one widely discussed hypothesis is that de- posits of Aβ ...

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Association between amylin and amyloid-β peptides in plasma in the context of apolipoprotein E4 allele.

Association between amylin and amyloid-β peptides in plasma in the context of apolipoprotein E4 allele.

... and amyloid-beta peptide (Ab), the main component of amyloid plaques and a major component of brain Alzheimer’s disease (AD) pathology, share several features, including similar b-sheet secondary structures ...

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Cross dimerization of amyloid-β and αsynuclein proteins in aqueous environment: a molecular dynamics simulations study.

Cross dimerization of amyloid-β and αsynuclein proteins in aqueous environment: a molecular dynamics simulations study.

... Self-assembly of the intrinsically unstructured proteins, amyloid beta (Ab) and alpha synclein (aSyn), are associated with Alzheimer’s Disease, and Parkinson’s and Lewy Body Diseases, respectively. Importantly, ...

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Amyloid β levels in human red blood cells.

Amyloid β levels in human red blood cells.

... Measurement of Ab40 and Ab42 in RBCs and Plasma For determination of Ab40 and Ab42 in RBCs, human b Amyloid (1–40) ELISA kits (WAKO, Osaka, Japan) and human b Amyloid (1–42) ELISA kits (WAKO) were used, ...

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Age-dependent neuroplasticity mechanisms in Alzheimer Tg2576 mice following modulation of brain amyloid-β levels.

Age-dependent neuroplasticity mechanisms in Alzheimer Tg2576 mice following modulation of brain amyloid-β levels.

... Phenserine treatment increased cortical synaptophysin levels in younger mice, while decreased interleukin-1 b and increased monocyte chemoattractant protein-1 and tumor necrosis factor-a[r] ...

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Distinct temporal and anatomical distributions of amyloid-β and tau abnormalities following controlled cortical impact in transgenic mice.

Distinct temporal and anatomical distributions of amyloid-β and tau abnormalities following controlled cortical impact in transgenic mice.

... Moderate to severe traumatic brain injury (TBI) can accelerate cognitive decline and increases the risk of dementia of the Alzheimer’s type [1,2,3,4,5]. Alzheimer’s disease (AD) is charac- terized by several pathological ...

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Effects of ligands on unfolding of the amyloid β-peptide central helix: mechanistic insights from molecular dynamics simulations.

Effects of ligands on unfolding of the amyloid β-peptide central helix: mechanistic insights from molecular dynamics simulations.

... the amyloid cascade hypothesis [1,2,3], accumulation of the amyloid b-peptide (Ab) in the brain is the primary influence driving AD ...the amyloid precursor protein ...

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Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.

Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.

... The Ca 2+ hypothesis, which introduced the concept of regulation by Ca 2+ of neuronal death both in age-related and in pathogenic processes, attempts to explain how disruptions in Ca 2+ homeostasis that continue over a ...

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Natural amyloid-β oligomers acutely impair the formation of a contextual fear memory in mice.

Natural amyloid-β oligomers acutely impair the formation of a contextual fear memory in mice.

... Natural amyloid-beta oligomer and control solutions A solution containing natural amyloid-beta (Abeta) oligomers was derived from the conditioned medium of 7PA2 cells (a kind gift of ...an amyloid ...

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Alzheimer's-related peptide amyloid-β plays a conserved role in angiogenesis.

Alzheimer's-related peptide amyloid-β plays a conserved role in angiogenesis.

... of Amyloid-b (Ab). Early versions of the amyloid hypothesis considered Ab something of an undesirable byproduct of APP processing that wreaks havoc on the human neocortex, yet evolutionary conservation - ...

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Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells.

Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells.

... elevated amyloid-b peptide (Ab) and loss of nicotinic acetylcholine receptors (nAChRs) being prominent ...Extracellular amyloid plaques, predominantly consisting of Ab, and intracellular neurofibrillar ...

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The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology

The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology

... Three indexes were calculated in order to evaluate both preference between objects and recognition of the novel object: 1) the object preference index, which is the ratio between the tim[r] ...

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Undetectable Levels of CSF Amyloid-β Peptide in a Patient with 17β-Hydroxysteroid Dehydrogenase Deficiency

Undetectable Levels of CSF Amyloid-β Peptide in a Patient with 17β-Hydroxysteroid Dehydrogenase Deficiency

... Although this protein has been genetically implicated in Alzheimer’s disease pathogenesis, studies of amyloid- ␤ peptide (A␤) in patients with HSD10 deficiency have not been previously reported. We found, in a ...

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Aminostyrylbenzofuran directly reduces oligomeric amyloid-β and reverses cognitive deficits in Alzheimer transgenic mice.

Aminostyrylbenzofuran directly reduces oligomeric amyloid-β and reverses cognitive deficits in Alzheimer transgenic mice.

... Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is characterized by the conformational transition of amyloid-b (Ab) into soluble oligomers, protofibrils and fibrils, which accumulate to ...

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