Antitumor effect
Antitumor effect of Bothrops jararaca venom
... an antitumor effect of treatment with specific snake venom fractions, others have reported no effects after this ...the effect of Bothrops jararaca venom (BjV) on Ehrlich ascites tumor (EAT) cells in ...
7
In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts
... Apoptosis is a genetically regulated programmed cell death phenomenon, and it is important in host defense and cancer sup- pression ( Khan et al., 2008 ). Many anticancer therapies work by inducing apoptosis in cancer ...
9
Synergistic antitumor effect of TRAIL and adriamycin on the human breast cancer cell line MCF-7
... apoptotic effect on MCF-7 ...synergetic antitumor effect of the combination of TRAIL and ADM on MCF-7 cells is due to the induction of cellular ...
10
Antitumor effect and toxicity of free rhodium (II) citrate and rhodium (II) citrate-loaded maghemite nanoparticles in mice bearing breast cancer
... exhibited antitumor effects against 4T1 metastatic breast cancer cell line following intratumoral ...This antitumor effect was followed by inhibition of both cell proliferation and ...
13
Identification of iGb3 and iGb4 in melanoma B16F10-Nex2 cells and the iNKT cell-mediated antitumor effect of dendritic cells primed with iGb3
... Natural killer T (NKT) cells are subsets of lymphocytes expressing the T-cell receptor (TCR) and surface markers characteristic of NK cells such as NK1.1. Type I NKT cells express an invariant T cell receptor α-chain, Vα ...
14
Targeted delivery of doxorubicin-loaded poly (ε-caprolactone)-b-poly (N-vinylpyrrolidone) micelles enhances antitumor effect in lymphoma.
... the resistant variants tested. Biodegradable micelles based on amphiphilic block copolymers such as poly (e-caprolactone) (PCL) have emerged as one of the most promising nano system for controlled and site-specific ...
17
Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)
... Systemic-Toxicity Evaluation. Body mass loss, organ weight alterations, and changes in the leukocyte counts were determined at the end of the in vivo antitumor-activity assay as previously described [10] [16] ...
8
Antitumor effect of laticifer proteins of Himatanthus drasticus (Mart.) Plumel Apocynaceae
... for suspended cells in 100 l of medium). After 24 h, the test sub- stance (0.39–50 g/ml), dissolved in saline, was added to each well (using the HTS—high-throughput screening—Biomek 3000; Beck- man Coulter Inc., ...
6
Rev. bras. farmacogn. vol.22 número2
... Cancer is one of the leading causes of mortality worldwide. Many of the chemotherapeutic agents used in the treatment of cancer injure rapidly dividing normal cells presenting substantial side effects. Therefore, the ...
10
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
... with antitumor, antibacterial, antifungal, antimalarial, antiprotozoal, antiparasitic, antiviral, anti-parasitic, anti-inflammatory activities has been ...the antitumor compounds from marine actinobacteria ...
21
Antitumor activity of quinazolinone alkaloids inspired by marine natural products
... synergistic effect against methicillin-resistant Staphylococcus aureus (MRSA) when combined with oxacillin ...Concerning antitumor activity, studies on quinazolinone compounds have mainly focused on natural ...
18
Study of antitumor and immunomodulatory activities of wild mushroom extracts
... no effect in the cell growth of primary cells of porcine liver ...the effect of the extract could be also analysed in animal models (namely in models of human tumor cell lines xenografted in nude mice) to ...
104
Rev. bras. farmacogn. vol.24 número4
... The Simaroubaceae family includes 32 genera and more than 170 species of trees and brushes of pantropical distribution. The main distribution hot spots are located at tropical areas of America, extending to Africa, ...
21
PPAR GAMMA AGONISTS: AN EFFECTIVE STRATEGY FOR CANCER TREATMENT
... To date, a number of important signaling mechanisms have been identified to underlie TZD-mediated antitumor activities. They are inhibition of Bcl-2/Bcl-xL function and repression of the expression of cyclin D1and ...
3
J. Braz. Chem. Soc. vol.26 número5
... 9 Lapachol ( 1 ) and β -lapachone ( 2 ) are quinones with notable activities and are representative of a select group of bioactive substances, which, for instance, exhibit antitumor[r] ...
15
J. Braz. Chem. Soc. vol.21 número7
... vitro antitumor screening and antibacterial activity of these compounds and of their copper(II) complexes (Scheme 1) against several cancer cell lines (SF-295, HCT-8, MDAMB-435 and HL-60) and bacteria strains ...
37
Assessment of estrogenic, mutagenic and antimutagenic activity of nemorosone
... Most anti-tumoral agents are designed to action cell proliferation (Green et al., 2011) and apoptosis induction (Peng et al., 2003). Drugs inhibit DNA synthesis by two mechanisms that are generally associated: the drug ...
7
J. Braz. Chem. Soc. vol.11 número2
... Since some substituted ethylenediamine platinum com- plexes have shown antitumor activity against a variety of cell tumors 14,15 , and since aromatic compounds have shown the possibility[r] ...
5
Arylated and dihydrofuran : , evaluation of antitumor activity and their correlation
... the antitumor activity of several substituted ␣- and -dihydrofuran naphthoquinones against 4 human tumor cell lines, HL-60 (leukemia), SF-295 (CNS), HCT-8 (colon) and MDA-MB435 (melanoma), and their ...
7
Biflorin : an o of clinical significance
... The quinones are a large and important class of substances present in nature and can be obtained as a synthetic product with a great variety of applications (Thomson 1987). The quinone structure was identi ied as an ...
8