B-catenin
NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt b-catenin signaling pathway
... Cells were lysed using ice-cold mammalian radio- immunoprecipitation assay (RIPA) buffer (Beyotime, China), containing a protease inhibitor cocktail (Invitrogen) and phenyl methanesulfonate (PMSF) (Invitrogen). Proteins ...
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Glycoprotein nonmetastatic melanoma protein B accelerates tumorigenesis of cervical cancer in vitro by regulating the Wnt b-catenin pathway
... protein B (GPNMB)-mediated cervical cancer ...nuclear b-catenin measured by western blotting in SiHa and HeLa cells as well as in normal cervical epithelial ...cells. B, Cells were treated by ...
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A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.
... Notably, DU4475, a human breast cancer cell line derived from a recurrent thoracic wall tumor following mastectomy due to a poorly differentiated invasive ductal carcinoma [19], carries a nonsense mutation at codon 1577 ...
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Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.
... Increased Wnt signaling in a mouse model of PDA Deregulation of Kras activity is observed in the vast majority of human PDA [1]. Activating mutations in the Kras oncogene have been observed in PanIN lesions, suggesting ...
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Synergistic inhibition of Wnt pathway by HIF-1α and osteoblast-specific transcription factor osterix (Osx) in osteoblasts.
... The current study also addresses possible mechanisms for hypoxia/HIF-1a to inhibit osteoblast proliferation. As a crucial mediator of hypoxia, HIF-1a is ubiquitous [29]. It is controversial how HIF-1a affects cell ...
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High glucose induces podocyte injury via enhanced (pro)renin receptor-Wnt-β-catenin-snail signaling pathway.
... Wnt-b- catenin pathway is involved in several developmental and pathologic processes including cancer [32,33], fibrosis[34,35], cystic disease [36], renal failure [37], and diabetic nephropathy ...
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E-cadherin acts as a regulator of transcripts associated with a wide range of cellular processes in mouse embryonic stem cells.
... sequester b- catenin protein and negatively interfere with its transcriptional function whilst E-cadherin down-regulation in epithelial cells has been implicated in higher b-catenin-mediated ...
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Wnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells.
... nuclear b-catenin in this GC cell line (Figure ...active b-catenin protein (S33Y) ...control, b-actin levels were determined. (B) Q-PCR for COX2, c-myc and CCND1 mRNA expression ...
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Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/β-catenin antagonist Chibby.
... In the present study, we describe the characterization of lung morphology and mechanics in Cby 2/2 mice. Consistent with Cby being a Wnt/b-catenin antagonist, b-catenin signaling is moder- ...
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Functional implications of microRNA-215 in TGF-β1-induced phenotypic transition of mesangial cells by targeting CTNNBIP1.
... After establishing that miR-215 regulated a-SMA and fibro- nectin expression in MMCs via a CTNNBIP1/b-catenin- dependent pathway, we expanded our study to investigate whether these mechanisms were important ...
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Long non-coding RNA LINC00261 sensitizes human colon cancer cells to cisplatin therapy
... nuclear b-catenin through restraining b-catenin from cytoplasm into nuclei or it could also promote b-catenin degradation and inhibit activation of Wnt ...
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Huaier aqueous extract inhibits ovarian cancer cell motility via the AKT/GSK3β/β-catenin pathway.
... of b- catenin and facilitating b-catenin nuclear ...that b-catenin plays a key role in epithelial ovarian cancer invasion and ...
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β-catenin is required for prostate development and cooperates with Pten loss to drive invasive carcinoma.
... As b-Catenin has been implicated in the progression of CRPC, we investigated if b- Catenin has a role in the continued growth of Pten deficient ...old b- Cat F/WT ;Pten F/F ;PBCre and ...
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FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo.
... of c-myc, a target of Wnt/b-catenin signaling which controls cell replication, and concomitantly reduced the expression of Axin2 and WISP-1 which are direct Wnt/b-catenin-target genes [3]. ...
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Modulation of β-catenin signaling by glucagon receptor activation.
... the b-catenin pathway leads to stabilization of b- catenin in the cytosol, which can translocate into the nucleus and associate with TCF transcription factors to activate TCF promoter–mediated ...
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Valproic acid induces cutaneous wound healing in vivo and enhances keratinocyte motility.
... of b-catenin, filaggrin, loricrin, keratin 14, or PCNA in the neo-epidermis of control and VPA- treated wounds (original magnification ...of b-catenin, filaggrin, loricrin, keratin 14, PCNA, ...
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Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis.
... maternal b-catenin ...of b-catenin2-MO in foxo3b morphants at 30% ...that b-catenin2-MO can successfully suppressed the increased expression of gsc in foxo3b morphants, and b-catenin2 ...
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Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma.
... by b-catenin ...hepatocyte-specific b-catenin KO livers as well as Hep3B cells expressing stable form of b-catenin, we show that LECT2 expression was indeed b- ...reflect ...
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Identification of proteins related to epigenetic regulation in the malignant transformation of aberrant karyotypic human embryonic stem cells by quantitative proteomics.
... late passages hESCs from three cell lines including chHES-8, chHES-69 and chHES-22. All three cell lines were able to differentiate into the three germ layers in vitro. This is consistent with most published studies, ...
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Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation.
... the b-catenin destruction complex and is also necessary for Wnt signaling initiation at the level of co-receptor ...Wnt/b- catenin signaling and to promote Axin protein ...
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