Blood-brain-barrier (BBB)
Vitamin D prevents hypoxia/reoxygenation-induced blood-brain barrier disruption via vitamin D receptor-mediated NF-kB signaling pathways.
... blood-brain barrier (BBB) disruption. Following hypoxic injury, an increase in intracellular reactive oxygen species (ROS) causes mitochondrial dysfunction, which further leads to intracellular ...
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Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves)
... the brain 5-HT, a little less than 2% of the indoleamine is produced in the central nervous system relative to the whole organism (Cooper et ...the blood brain barrier (BBB) towards the ...
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Treatment with the NK1 antagonist emend reduces blood brain barrier dysfunction and edema formation in an experimental model of brain tumors.
... the blood-brain barrier (BBB) and development of cerebral edema in acute brain ...around brain tumors and has been linked to several tumor-associated ...of brain peritumoral ...
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Spatiotemporal correlations between blood-brain barrier permeability and apparent diffusion coefficient in a rat model of ischemic stroke.
... and blood-brain barrier (BBB) permeability after ischemia have been suggested, though the correlation between ADC alterations and BBB opening remains to be ...
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Opiates Upregulate Adhesion Molecule Expression in Brain MicroVascular Endothelial Cells (BMVEC): Implications for Altered Blood Brain Barrier (BBB) Permeability
... Blood-brain barrier model: The BBB model is established in our laboratory using primary human BMVEC and normal human astrocytes (NHA). Primary cultures of both human BMVEC and NHA to constitute the ...
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Machine learning algorithms to predict blood-brain barrier permeability of drug molecules
... the brain, the tendency to cause side effects on CNS, and the existency of the Blood-Brain Barrier (BBB) that CNS drugs have to cross [Alavijeh et ...
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Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction.
... the blood-brain barrier (BBB) is compromised due to an increase in exposure to pro-inflammatory media- tors, viral proteins, and virus released from infected ...
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Vascular endothelial growth factors enhance the permeability of the mouse blood-brain barrier.
... The blood-brain barrier (BBB) impedes entry of many drugs into the brain, limiting clinical ...significant brain edema was observed by diffusion weighted MRI (DWI) or histological ...
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Targeted brain derived neurotropic factors (BDNF) delivery across the blood-brain barrier for neuro-protection using magnetic nano carriers: an in-vitro study.
... agent; brain derived neurotropic factor (BDNF), which protects neurons against these effects, could be of therapeutic benefit in the treatment of opiate ...the blood brain barrier (BBB) ...
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Fingolimod prevents blood-brain barrier disruption induced by the sera from patients with multiple sclerosis.
... the blood, thereby reducing autoaggressive lymphocyte infil- tration into the central nervous system (CNS) ...on brain microvascular endothelial cells (BMECs) comprising the blood-brain ...
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Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3 Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain.
... The blood-brain barrier (BBB) is a highly selective permeability barrier separating the blood stream from the interstitial fluid in the ...This barrier controls the nutrient ...
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A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells.
... human blood brain barrier (BBB) is a selective barrier formed by human brain endothelial cells (hBECs), which is important to ensure adequate neuronal function and protect the central ...
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Sex-specific signaling in the blood-brain barrier is required for male courtship in Drosophila.
... agreement with the overall reduction in courtship (Table 1). These data show that males with feminized blood–brain barrier are capable of all steps of courtship, but perform them with reduced ...
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Preservation of the blood brain barrier and cortical neuronal tissue by liraglutide, a long acting glucagon-like-1 analogue, after experimental traumatic brain injury.
... the brain parenchyma plays a key role in edema formation ...acute brain injury, for instance Exendin-4 reduced IBA-1 positive microglia activation in experimental model of global ischemia and in stroked ...
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Nanoparticle mediated P-glycoprotein silencing for improved drug delivery across the blood-brain barrier: a siRNA-chitosan approach.
... The blood-brain barrier (BBB), composed of tightly organized endothelial cells, limits the availability of drugs to therapeutic targets in the central nervous ...The barrier is maintained by ...
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Inflammation Modulates RLIP76/RALBP1 Electrophile-Glutathione Conjugate Transporter and Housekeeping Genes in Human Blood-Brain Barrier Endothelial Cells.
... Treatment of human endothelial cells in a BBB model with TNF-α led to the induction of sev- eral inflammation markers indicating an inflammatory response. Under these conditions, the expression of housekeeping genes such ...
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Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke
... Docosahexaenoic acid (DHA) and neuroprotectin D1 (NPD1) are neuroprotective after experimental ischemic stroke. To explore underlying mechanisms, SD rats underwent 2 h of middle cerebral artery occlusion (MCAo) and ...
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Pharmacokinetic analysis of 111 in-labeled liposomal Doxorubicin in murine glioblastoma after blood-brain barrier disruption by focused ultrasound.
... of blood-brain barrier disruption (BBB- D) induced by focused ultrasound ...intracranial brain tumor model in NOD-scid mice using human brain glioblastoma multiforme (GBM) 8401 cells ...
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Blood brain barrier and neuroinflammation are critical targets of IGF-1-mediated neuroprotection in stroke for middle-aged female rats.
... the blood brain barrier of older animals by directly enhancing survival of endothelial cells, although such actions may be limited during the early phase of ...promote barrier integrity by ...
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Estrogen provides neuroprotection against brain edema and blood brain barrier disruption through both estrogen receptors α and β following traumatic brain injury
... after TBI, it was observed this compound did not reduce brain edema, and BBB permeability. In other words, MPP has no agonist effect on ER . This finding is consistent with other studies that have reported that ...
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