Central nervous system tumors
Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the Central Nervous System
... Many delivery systems for CNS therapies are designed to take advantage of BBB transportation pathways in order to improve their effectiveness [185]. The transport of NPs across the BBB can happen through different ...
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Multicentric lymphoma with metastasis in the central nervous system in a dog
... Lymphoma within the CNS develops most commonly as part of a multicentric or systemic process (Long et al., 2001), as observed in this report. The clinical signs produced by CNS tumors are nonspecific and depend on ...
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Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine
... Dendrimers present optimal guest–host properties for accommodation of different chemical drugs. These can be contained inside dendrimers (“dendritic box” model, Figure 4a)48 through non‐ covalent interactions: ...
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Impact of Mechanotransduction in the Context of Central Nervous System Diseases
... of tumors may be explained by mechanotransduction of flow forces, and that fluid shear stress may lower glioma cells motility through modulation of the activation of matrix metalloproteinases ...a central ...
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The metabolism of central nervous system metastasis: cerebrospinal fluid metabolome
... lymphatic system, evade immune attack, extravasate at a distant capillary bed, and invade and proliferate in distant organs (Bacac & Stamenkovic, 2008; Chamberset ...
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Expression of CD150 in tumors of the central nervous system: identification of a novel isoform.
... CNS tumors and glioma cell ...CNS tumors, CD150 could be a novel diagnostic marker for CNS tumors and a potential target for the therapy of ...
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Gene expression alterations in central nervous system neoplasms with EGFR amplification
... The TP53/MDM2/p14 ARF pathway is responsible for maintaining DNA integrity prior to cell division. TP53 (a tumor suppressor gene, coding for the p53 protein) is one of the most important and tightly regulated genes of ...
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Developmental adaptation of central nervous system to extremely high acetylcholine levels.
... cholinergic system (CHT, VAChT, ChAT, NR, MR, AChE) appear already during the embryonal develop- ment in rodents and show a rapid age-related increase during the first three weeks of postnatal ...
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IMPROVED DIAGNOSIS OF CENTRAL NERVOUS SYSTEM TUBERCULOSIS BY MPB64-TARGET PCR
... Central nervous system (CNS) tuberculosis is a serious clinical problem, the treatment of which is sometimes hampered by delayed diagnosis. Clearly, prompt laboratory diagnosis is of vital importance ...
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Central nervous system imaging in girls with central precocious puberty: when is necessary?
... Objectives: The determinants of an increased risk of an organic pathology underlying central precocious puberty (CPP) in girls remain contentious. The present study aimed to determine the clinical and hormonal ...
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Paracoccidioidomycosis case series with and without central nervous system involvement
... Introdução: A paracoccidioidomicose (PCM) é a micose profunda mais importante na América do Sul. O comprometimento do sistema nervoso central é grave e pode ocorrer em 12,5% dos casos. Este trabalho tem como ...
5
Recent developments in microfluidic technologies for central nervous system targeted studies
... neural and vascular cell differentiation. Furthermore, western blot showed the presence of TJ protein ZO-1. The integrity and tightness of the barrier was assessed with Alexafluor TM -conjugated dextran leakage, perfused ...
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Primary central nervous system lymphoma: relevant strategies for the initial management
... rimary central nervous system (CNS) lymphoma (PCNSL) is a relatively uncommon and aggressive extranodal non-Hodgkin lymphoma arising exclusively in the CNS that quite often presents a diagnostic ...
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The role of surgery in primary central nervous system lymphomas
... Introducción: Los linfomas primarios del sistema nervioso central (LPSNC) son infrecuentes. Tradicionalmente el tratamiento de elección es la quimioterapia. Existe un paradigma de no indicar resección, por el ...
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Tuberculosis of the central nervous system in cattle in Paraíba, Brazil
... the central nervous system (CNS) of cattle in the state of Paraíba in northeastern ...exclusively nervous signs, two had respiratory signs and weight loss and one did not present any clinical ...
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Development of human central nervous system 3D in vitro models for preclinical research
... described system is actually limited, for 3D imaging, by the scanning method, where the sample is moved through the light sheet at relatively slow speeds, allowing a maximum of four frames per second at full ...
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A Case Of Primary Central Nervous System Vasculitis Who Presented With Status Epilepticus
... 6. Schmidley JW. Vascular Diseases of the Nervous System : Central Nervous System Vasculitis. In: Daroff RB, Fenichel GM, Jankovic J and Mazziotta JC eds. Bradley's Neurology in ...
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Searching for the role of lipocalin-2 in the central nervous system
... It is also possible that during development, LCN2 has a differential expression pattern, which deserves further investigation and may provide additional clues regarding its mechanism of action. The precise mechanisms ...
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Suppurative infectious diseases of the central nervous system in domestic ruminants¹
... Central nervous system (CNS) diseases affecting domestic ruminants comprise conditions that cause economic losses globally, and bacterial infections are important causes of mortality and, also, ...
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Multiple myeloma and central nervous system involvement: experience of a Brazilian center
... after central nervous system ...tral nervous system infiltration at diagnosis of multiple ...after central nervous system ...with central nervous ...
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