Complement factor H
Thrombotic Microangiopathy with Complement Factor H Gene Mutations Unassociated with Atypical Hemolytic Uremic Syndrome
... Atypical hemolytic uremic syndrome (aHUS) is a rare multigenic disorder characterized by thrombotic microangiopathy (TMA). Among the genes that are associated with aHUS, mutations in the complement factor ...
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Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration.
... We also analyzed the HTRA1 rs 11200638 polymorphism (Table S2). LOC387715 rs10490924 and HTRA1 rs11200638 are located only 6.1 kb from each other, and correspondingly, we observed only 5 genotypes out of 787 that were ...
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Interaction of complement factor h and fibulin3 in age-related macular degeneration.
... Age-related macular degeneration (AMD) is a major cause of vision loss. It is associated with development of characteristic plaque-like deposits (soft drusen) in Bruch’s membrane basal to the retinal pigment epithelium ...
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Alterations of choroidal blood flow regulation in young healthy subjects with complement factor H polymorphism.
... the complement factor H gene (rs1061170, Y402H) is associated with a high risk of age-related macular degeneration ...the complement system ...
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Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3.
... human complement regulator in blood, complement factor H (FH), has several closely related proteins, called FH-related (FHR) ...ing complement-mediated ...
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The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.
... Purified Factor H bound to intact bacteria, but dependent on the assay showed weak or even no binding to Sbi (compare Figure 1, Figure 3B and Figure ...of Factor H and C3 to ...with ...
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Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi.
... B. burgdorferi employs multiple strategies to survive in and persistent in the human host. One central immune evasion strategy is the ability of borreliae to camouflage their surface with host fluid phase ...
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Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.
... study. Y402H (rs1061170) is the most studied non-synonymous SNP of CFH. Y402H is located in SCR7 and affects the binding of CFH with glycosaminoglycans and CRP [22,23,24]. Y402H has been strongly associated with risk of ...
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Affinity purification of human factor H on polypeptides derived from streptococcal m protein: enrichment of the Y402 variant.
... Recent studies indicate that defective activity of complement factor H (FH) is associated with several human diseases, suggesting that pure FH may be used for therapy. Here, we describe a simple ...
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Atypical haemolytic-uraemic syndrome caused by factor H mutation: case report and new management strategies in children
... encoding complement factor H revealed a heterozygous SCR20 mutation [(3644G>T, resulting in the exchange of arginine by leucine at position 1215 (Arg1215Leu)] that confirmed the ...of ...
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The interaction between factor H and Von Willebrand factor.
... Complement factor H (fH) is a plasma protein that regulates activation of the alternative pathway, and mutations in fH are associated with a rare form of thrombotic microangiopathy (TMA), known as ...
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O OH H CH H O C H CH ALTERNARIOL ALTERNARIOL MONOMETHYL ETHER 3
... containing 300 mg ZnSO 4 . H 2 O/L, 0.7 ml/min. The wavelength for recording chromatograms was 250 nm. A calibration curve was constructed for quantification purposes using the toxin standards and correlating ...
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Graphs cospectral with a friendship graph or its complement
... Spec(H) for some graph H, then G ∼ = H. So far numerous examples of cospectral but non-isomorphic graphs are constructed by interesting techniques such as Seidel switching, Godsil-McKay switching, ...
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Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4.
... In particular, C4 is involved in the classical and mannose- binding lectin pathways of the complement system, and it is responsible for the major activity of complement components. Upon antibody binding to ...
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Diferentes demonstrações para o limite: lim sen(h)/h quando h->o
... h . Todas essas demonstrações são simples de serem realizadas e, na minha opinião, poderiam ser apresentadas para os alunos durante os cursos de cálculo. Eu mesma só conhecia a demonstração denominada como ...
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Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats.
... inhibit complement activity in Wistar rat serum in vitro (S2 ...block complement activation in blood, we performed a dosing study in which this peptide was delivered IV into jugular catheterized Wistar rats ...
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The Companion paper as a complement to regular papers
... The Companion manuscript should be based on a pub- lished or accepted article (the source article) where the analysis to be described is not the main focus of the text and where it is us[r] ...
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Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status.
... 54. Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, Hageman JL, Stockman HA, Borchardt JD, Gehrs KM, Smith RJ, Silvestri G, Russell SR, Klaver CC, Barbazetto I, Chang S, Yannuzzi LA, Barile GR, ...
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ESTRUTURA CURRICULAR 2014/1. 60 h. 104 h. 146 h. 72 h 2º SEMESTRE. Carga horária
... 64 h Clínica Médica / Cirurgia / Pediatria MED034, MED035, MED036, MED037, MED038, MED040 Cirurgia ambulatorial 32 h Cirurgia Geral MED034, MED035, MED036, MED037, MED038, MED041 Traumato-Ortopedia 32 ...
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H. H. Price, Paradigmas e o problema dos universais
... Como paradigmas não são determinados de maneira objetiva, o Nominalismo de Price pode ser rotulado como uma solução subjetivista para o problema dos universais.. P[r] ...
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