dengue virus capsid protein
Understanding dengue virus capsid protein interaction with key biological targets
... Dengue virus (DENV) causes a mosquito-borne disease that leads to over half a million hospitalizations and 20,000 deaths worldwide every year 1–4 ...well-known dengue hemorrhagic fever and the often ...
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Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium ion dependent and is mediated by LD surface proteins
... studied protein-LD complex were con- structed, choosing the ideal bin size to achieve the best-fitted Gaussian model peak ...C protein molecule rupture force can be determined by fitting the distributions ...
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Intracellular nucleic acid delivery by the supercharged dengue virus capsid protein
... or protein-based therapies are limited by the difficult cellular internalization of these macromolecules ...regular protein by means of amino acid mutations) may serve as potent drug delivery systems into a ...
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Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production via Interaction with the Structural Proteins.
... with capsid arguing for a second function of NS1 in the assembly of DENV particles that is indepen- dent from envelope protein ...with capsid, as a consequence of altered interactions with other ...
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Cellular promyelocytic leukemia protein is an important dengue virus restriction factor.
... Dengue virus (DENV) is an emerging mosquito-borne human pathogen included in the family Flaviviridae. The four DENV serotypes (DENV1-4) affect millions of individuals each year by causing severe and ...
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West Nile virus capsid protein interacts with biologically relevant host lipid systems
... and dengue viruses are closely related flaviviruses, originating mosquito-borne viral infections for which there are no effective and specific ...Their capsid proteins sequence and structure are ...
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The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly.
... of protein phosphorylation in the assembly of flaviviruses have been ...NS5A protein is critical for its interaction with the core protein for the production of infectious virus particles in ...
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Interaction of West-Nile virus capsid protein with lipid systems
... West-Nile Virus (WNV) is a single-strand positive RNA virus of the Flaviviridae family that was first isolated in Uganda in 1937 (Kilpatrick, ...as dengue and yellow fever viruses), the globalization ...
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Worldwide spread of Dengue virus type 1.
... Complete envelope sequences (E gene) of DENV-1 with known time (year) and geographical locality (country) of isolation were retrieved from GenBank (1583 envelope gene sequences from 45 distinct geographic locations, data ...
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Dengue virus infection presenting with diffuse brain hemorrhage
... A 40-year-old woman presented to the emergency department with acute decreased level of consciousness, associated with respiratory failure. She has complained of headache, fever, myalgia and dyspnea for the last seven ...
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Lentiviral Gag assembly analyzed through the functional characterization of chimeric simian immunodeficiency viruses expressing different domains of the feline immunodeficiency virus capsid protein.
... with virus budding from the host cell, the Gag precursor is cleaved by the virus-encoded protease into its functional domains ...the protein-protein interactions that drive Gag multimerization ...
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Dengue virus type 3 in Brazil: a phylogenetic perspective
... rently responsible for more deaths worldwide than any other arthropod-transmitted human viral disease, and are emerging as a major problem in tropical and sub- tropical areas (Rosen 1999). The ~11 kb-long genomic RNA of ...
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Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases
... The prevalence of laboratory indicators of recent or current infection by arboviruses among the neurologi- cal cases registered during the studied period contrasts with previous descriptions from non-tropical countries, ...
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In vitro and in vivo studies identify important features of dengue virus pr-E protein interactions.
... as dengue virus (DENV), West Nile virus (WNV), tick-borne encephalitis virus (TBEV) and yellow fever virus ...in dengue fever endemic areas, and there are an estimated 50–100 ...
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SEQUENCE ANALYSIS OF THE CAPSID PROTEIN GENE OF AN ISOLATE OF Apple stem grooving virus, AND ITS SURVEY IN SOUTHERN BRAZIL
... of virus-tolerant rootstocks, Brazilian apple production has been increasing considerably in recent decades and in 2000 has reached approximately 850,000 tons (Brazilian Apple Growers Association, ABPM) mainly ...
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Low sensitivity of NS1 protein tests evidenced during a dengue type 2 virus outbreak in Santos, Brazil, in 2010
... leukemia virus RT (Invitrogen, ...from dengue virus serotypes as follows: 482 bp for DENV-1, 119 bp for DENV-2, 290 bp for DENV-3, and 389 bp for ...respective dengue virus serotypes ...
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Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development
... a Dengue IgG/IgM Lafon® immunochromatographic cassette (Standard Diagnostics, ...with Dengue IgM Cap- ture ELISA (E-DEN01M/E-DEN01M05) and Dengue IgG Capture ELISA (E-DEN02G PanBio®, Brisbane, ...
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Expression of enterovirus 71 capsid protein VP1 in Escherichia coli and its clinical application
... Fecal specimens were mixed thoroughly with 5 to 10 volumes of phosphate-buffered saline (PBS) (pH 7.4) to generate homogeneous suspensions. The mixtures were clarified by centrifugation at 13, 000 g for 5 min. Viral RNA ...
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The Aedes aegypti toll pathway controls dengue virus infection.
... that dengue infection activates the Toll immune signaling pathway, we designed experiments to assess the relationships between dengue infection-responsive gene regulation and Rel1- and Rel2-controlled gene ...
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MOLECULAR TYPING OF DENGUE VIRUS TYPE 2 IN BRAZIL
... of dengue virus over the last 15 years could explain the genetic diversity observed in DEN-2 viruses analyzed in this study, since they were isolated between 1990 and ...
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