Dll4/ Notch
Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models
... of Dll4-Notch signaling, and here we show that Dll4-Notch signaling acts a genetic determinant of native arterial collateral ...4. Dll4 +/− mice show reduced functional recovery after ...
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Modulating the bone marrow microenvironment:the role of DLL4:Notch signaling and hypoxia
... setting of BM transplant (BMT). We found that anti-Dll4 treatment following myeloablation induces mild BM vascular and hematopoietic changes, and Dll4 may be an interesting therapeutic target in BMT. We ...
184
Dll4-notch signalling blockade synergizes combined ultrasound-stimulated microbubble and radiation therapy in human colon cancer xenografts.
... (3) Dll4 mAb, (4) XRT and Dll4 mAb, (5) ultrasound-stimulated microbubbles (USMB) combined with XRT, or (6) a triple combination of USMB, XRT and Dll4 ...the Dll4 monoclonal antibody (mAb; ...
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SIRT1 regulates endothelial Notch signaling in lung cancer.
... Wild-type and SIRT1-transgenic mice were subcutaneously injected in the abdomen with 500 m L of growth factor-reduced Matrigel (BD Biosciences, USA) containing 200 ng FGF2 (R&D Systems) and 60 U/mL heparin ...
11
Endothelial Dll4 overexpression reduces vascular response and inhibits tumor growth and metastasization in vivo
... by Dll4/Notch genetic or pharmacologic inhib- ition when we look at the endothelial or smooth muscle cell layer ...thelial Dll4 loss- and gain-of-function resulted in impaired wound regeneration ...
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The role of the Delta-like 4 Notch ligand in tumor angiogenesis
... In Dll4 +/- mice or sDll4 treated mice, the defects in vessel maturation may be in part be explained by the impaired Notch3 signaling, which is critical for mural cell function (Domenga, Fardoux et ...after ...
223
The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells
... the Notch signal- ing pathway, and to mediate increased proliferation of cells transfected with active Notch [ 41 ...the Notch signaling pathway and its upregulation by DLL4-Notch ...
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The role of endothelial Dll4 in cancer metastasis
... long-term Dll4/Notch-suppression may revert tumor growth, par- ticularly in association with increasing malignant cell inva- siveness, previously documented as a consequence of antiangiogenic-induced ...
145
Filtro Notch para aplicações em EEGs e ECCs, com recurso a técnicas de F&H em CMOS
... Tabela 4.4: Parâmetros calculados para implementação do filtro fazer um ajuste da tensão de polarização Vbias do circuito CMFB de modo a tornar centralizar a saída em 1.65V.. Figura 4.15[r] ...
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Mastermind-Like 1 Is Ubiquitinated: Functional Consequences for Notch Signaling.
... MAML1 has been previously shown to be a general co-activator of numerous transcription fac- tors including MEF2C, p53, and Notch. Overexpression of MAML1 with N1ICD increased HES1 promoter activation compared to ...
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Insensible is a novel nuclear inhibitor of Notch activity in Drosophila.
... by Notch receptors [1]. Trans-membrane receptors of the Notch family can be described as membrane-tethered transcriptional regulators ...of Notch is thought to result in ectodomain shedding and ...
10
Realization of Band-Notch UWB Monopole Antenna Using AMC Structure
... The Antenna-1 is simulated with the single EBG cell and double EBG cells (Antenna-2), and their responses are compared with the reference antenna (Antenna-1) as shown in Fig. 9. It can be observed from the figure that ...
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Regulation of neuronal production in the retina by Notch signaling
... [1] Henrique D, Hirsinger E, Adam J, Le Roux I, Porquie O, Ish-Horowicz D, Lewis J: Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina. Current Biology 1997, 9: ...
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Three distinct roles for notch in Drosophila R7 photoreceptor specification.
... To determine whether the normal up-regulation of sev tran- scription in the R7 precursor depends on N activity, we performed the reciprocal experiment of assaying sev.lacZ expression in omma- tidia in which the N ...
13
Remoção da interferência de 60 hz no sinal de ECG usando filtro notch digital / Removal of 60 Hz interference on the ECG signal using digital notch filter
... 60 Hz AC interference can be a problem in any biopotential measurement situation. The source of such interference is the AC potential of the electrical power supply network that is inevitably present in any clinical ...
12
LKB1 and Notch Pathways Interact and Control Biliary Morphogenesis.
... that Notch activation is deficient in the absence of ...and Notch signaling extends beyond bile duct ...and Notch signaling, and characterized the activation status of the Notch pathway in ...
16
The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled.
... Embryo fixation, antibody staining and in situ hybridization were carried out by standard protocols [10]. The following primary antibodies were used: rabbit a-Cno, 1/500 [25]; rat a-Cno [53], mouse a-CD2, 1/800 ...
12
Monitoring the activity of the Notch pathway in neural progenitor cells
... The Notch signaling pathway, through lateral inhibition, is involved in this balance, restraining NP ...about Notch activity in single NPs, mainly regarding possible variations on Notch activity in ...
59
Perivascular delivery of Notch 1 siRNA inhibits injury-induced arterial remodeling.
... between Notch signaling and vSMC growth in vitro and in vivo is now well established [29] [2] ...induced Notch stimulation results in robust Figure ...of Notch 1 siRNA prevents injury-induced ...
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