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Glioblastoma cells

Bioactive form of resveratrol in glioblastoma cells and its safety for normal brain cells

Bioactive form of resveratrol in glioblastoma cells and its safety for normal brain cells

... U251 cells reached apoptotic peak at 48-hour time point, which suggested that the metabolic mechanism pre-existed in the tumor cells apoptosis and its efficiency was enhanced in response to resveratrol ...

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Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells.

Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells.

... Several approaches are available to identify miRNA targets, starting with multiple target prediction methods and continuing with a variety of biological procedures that include reporter based screenings, shotgun ...

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Kaurene diterpene induces apoptosis in U87 human malignant glioblastoma cells by suppression of anti-apoptotic signals and activation of cysteine proteases

Kaurene diterpene induces apoptosis in U87 human malignant glioblastoma cells by suppression of anti-apoptotic signals and activation of cysteine proteases

... cancer cells can only survive if the apoptotic response is dampened or disrupted, cell cycle checkpoints are evaded, and unre- stricted cell proliferation is allowed to ...in glioblastoma cell lines may ...

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Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.

Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.

... U251 cells (5610 6 ) were injected into the right hind flank ...growing glioblastoma cell lines and normal human astrocytes (NHA) were (A) treated with SubA or EGF-SubA at the specified picomolar ...

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Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.

Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.

... Accumulating reports indicate that ROS function as important physiological regulators of diverse intracellular signaling pathways, such as growth factor stimulation and inflammatory responses [35]. Dysregulated ROS ...

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REST controls self-renewal and tumorigenic competence of human glioblastoma cells.

REST controls self-renewal and tumorigenic competence of human glioblastoma cells.

... GB cells are critically dependent on REST activity and that inhibition of REST-regulated pathways might disclose potentially exploitable strategies towards GBM treatment in ...positive cells in diverse ...

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Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients.

Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients.

... reduced bony metastases by over 50%. The authors also showed that CD97 heterodimerizes and positively regulates lysopho- sphatidic acid receptor 1 (LPAR1) signaling, a well-established mediator of tumorigenesis and ...

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The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells.

The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells.

... The cells were grown to semi- confluency and then treated with LLL12 for either 6 or 24 ...experiments, cells were pretreated with LLL12 for 2 hours and then treated with IL-6 for 30 minutes before being ...

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Analysis of the cytotoxicity of carbon-based nanoparticles, diamond and graphite, in human glioblastoma and hepatoma cell lines.

Analysis of the cytotoxicity of carbon-based nanoparticles, diamond and graphite, in human glioblastoma and hepatoma cell lines.

... EGFP-expressing glioblastoma and hepatoma cells was ...of cells, such as human cervical cancer cell line (HeLa), mouse pre-adipocyte (3T3-L1) and osteoprogenitor cell line (489-2) [19], as well as ...

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Rev. bras. farmacogn.  vol.27 número3

Rev. bras. farmacogn. vol.27 número3

... of glioblastoma tumors in several ...on glioblastoma cells. Human A172 glioblastoma cells were treated with increasing concen- trations of bee ...

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Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.

Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.

... To detect JMJD3 interacting proteins, empty vector (p3xFLAG- CMV, Sigma) and JMJD3-Flag were transfected into HEK293 cells using Lipofectamine 2000 (Invitrogen). 2 days following transfection, cells were ...

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Expression of CD150 in tumors of the central nervous system: identification of a novel isoform.

Expression of CD150 in tumors of the central nervous system: identification of a novel isoform.

... B cells were isolated by density fractionation on discontinuous Lymphoprep (Axis-Shield PoC AS, Norway) and Per- coll (Sigma, USA) gradients as described ...T cells were further cultured in RPMI 1640 medium ...

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Isolation of cancer stem cells from three human glioblastoma cell lines: characterization of two selected clones.

Isolation of cancer stem cells from three human glioblastoma cell lines: characterization of two selected clones.

... differentiating cells confirm that our clones are unable to differentiate in ...GBM cells as a second messenger to support cell migration and oscillatory changes in intracellular Ca 2+ concentration ...

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Modelagem matemática e computacional no crescimento do glioblastoma multiforme / Modelagem matemática e computacional no crescimento do glioblastoma multiforme

Modelagem matemática e computacional no crescimento do glioblastoma multiforme / Modelagem matemática e computacional no crescimento do glioblastoma multiforme

... O Glioblastoma Multiforme (GBM) é o tipo mais recorrente de tumor cerebral maligno em adultos, segundo Sousa et al. (2002). Este, provoca uma proliferação celular anormal, excessiva e descoordenada, que não cessa ...

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Radiological imaging features of glioblastoma with oligodendroglioma component: a comparison with conventional glioblastoma

Radiological imaging features of glioblastoma with oligodendroglioma component: a comparison with conventional glioblastoma

... (4). Glioblastoma with oligodendroglioma component (GBMO) is a subtype of conventional glioblastoma (cGBM), which is categorized as grade IV in the WHO classification 2007 ...both glioblastoma and ...

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NTRK1 fusion in glioblastoma multiforme.

NTRK1 fusion in glioblastoma multiforme.

... 3T3 cells increased proliferation in vitro, colony formation in soft agar, and tumor formation in mice, suggesting the possibility that the fusion contributed to the initiation or maintenance of the ...

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Proportional upregulation of CD97 isoforms in glioblastoma and glioblastoma-derived brain tumor initiating cells.

Proportional upregulation of CD97 isoforms in glioblastoma and glioblastoma-derived brain tumor initiating cells.

... CD97 is a novel glioma antigen that confers an invasive phenotype and poor survival in pa- tients with glioblastoma (GBM), the most aggressive primary malignant brain tumor. The short isoform of CD97, known as ...

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Relative Biological Effectiveness (RBE) of 131I Radiation Relative to 60Co Gamma Rays

Relative Biological Effectiveness (RBE) of 131I Radiation Relative to 60Co Gamma Rays

... energy transfer (LET) radiations have the same quality factor (QF), they seem to exert differ- ent biological effects. Determination of RBE is a comprehensive way to compare effects of these two low LET radiations. ICRP ...

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Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway.

Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway.

... It is generally accepted that ferritin is the primary iron storage protein, but recent studies have demonstrated that it may also be pivotal to cell proliferation, angiogenesis, and immunosup- pression [6]. Tumor ...

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AQP9 expression in glioblastoma multiforme tumors is limited to a small population of astrocytic cells and CD15(+)/CalB(+) leukocytes.

AQP9 expression in glioblastoma multiforme tumors is limited to a small population of astrocytic cells and CD15(+)/CalB(+) leukocytes.

... expressing cells may include ...human glioblastoma tissue (data not ...myelomonocytic cells, we observed clear but weaker immunolabeling of larger cells in sections obtained from one patient ...

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