Guanylate Cyclase
Role of soluble guanylate cyclase activation in the effect of the HO1CO pathway against alendronateinduced gastricdamage in rats
... To investigate the role of cGMP in the gastroprotective effect of CO, rats were pretreated with ODQ (guanylate cyclase inhibitor: 10 mg/kg, i.p.). One hour before, the rats received hemin (HO-1 inducer: 10 ...
9
Vasodilator e ffects and putative guanylyl cyclase stimulation by 2-nitro-1- phenylethanone and 2-nitro-2-phenyl-propane-1,3-diol on rat aorta
... group in a short aliphatic chain connected to an aromatic group. In this study, we evaluated in rat aorta the effects of two nitro compounds, with emphasis on a putative recruitment of the soluble guanylate ...
10
Carbon monoxide: from toxin to endogenous modulator of cardiovascular functions
... soluble guanylate cyclase (8) and relax preparations of vascular smooth muscle (11) have prompted suggestions that carbon monoxide may lower blood pressure by promoting vasodilation ...
14
Genetic responses against nitric oxide toxicity
... The threat of free radical damage is opposed by coordinated responses that modulate expression of sets of gene products. In mammalian cells, 12 proteins are induced by exposure to nitric oxide (NO) levels that are ...
11
Instituto de Investigação Química e Biológica António Xavier, UNL
... Soluble guanylate cyclase (sGC) is a heterodimeric heme-protein composed of two subunits called α and β [1-5]. The most common heterodimeric form is the combination of α1 with β1 subunits [1]. The α1 ...
194
Differential contribution of the guanylyl cyclase-cyclic GMP-protein kinase g pathway to the proliferation of neural stem cells stimulated by nitric oxide
... Nitric oxide (NO) is an important inflammatory mediator in- volved in the initial boost in the proliferation of neural stem cells following brain injury. However, the mechanisms un- derlying the proliferative effect of ...
13
From Escherichia coli heat-stable enterotoxin to mammalian endogenous guanylin hormones
... The holoprotein is a homodimeric protein with a multidomain structure consisting of a) N-terminal extra- cellular domain (ECD), b) single helical transmembrane region, c) juxtamembrane domain, d) kinase homology domain ...
13
Cellular signaling with nitric oxide and cyclic GMP
... During the past two decades, nitric oxide signaling has been one of the most rapidly growing areas in biology. This simple free radical gas can regulate an ever growing list of biological processes. In most instances ...
11
Signaling governed by G proteins and cAMP is crucial for growth, secondary metabolism and sexual development in Fusarium fujikuroi.
... A prominent downstream target of heterotrimeric G proteins is the adenylyl cyclase. The activated enzyme produces cAMP which in turn activates the PKA via binding to its regulatory subunit [11]. In order to find ...
14
Light modulates the melanophore response toa -MSH in Xenopus laevis: An
... Melanin granule (melanosome) dispersion within Xenopus laevis melanophores is evoked either by light or a -MSH. We have previously demonstrated that the initial biochemical steps of light and a -MSH sig- naling are ...
7
Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activity.
... Nitric oxide signals through activation of soluble guanylyl cyclase (sGC), a heme-containing heterodimer. NO binds to the heme domain located in the N-terminal part of the b subunit of sGC resulting in increased ...
8
Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation.
... Results: We now demonstrate that Angeli’s salt inhibits Ang II-induced hypertrophic responses in cardiomyocytes, including increases in cardiomyocyte size, de novo protein synthesis and b-myosin heavy chain expression. ...
11
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans.
... To specifically test the role of this lysine in the bicarbonate activation of Cyr1p and to generate an AC with a selective defect in its bicarbonate responsiveness, we generated strains containing mutant/WT heterodimers. ...
11
STC1 interference on calcitonin family of receptors signaling during osteoblastogenesis via adenylate cyclase inhibition
... on coordinated functions of bone forming (osteoblasts), resident (osteocytes) and resorbing cells (osteoclasts) that are regulated by several local and endocrine factors that act on calcium and phos- phate homeostasis ...
10
Int. braz j urol. vol.36 número2
... In the present study they found evidence that growth hormone may act on human corpus cavernosum by an effect independent of nitric oxide on guanylyl cyclase activity. The group has to be commended for the ...
2
Adenylyl cyclase types I and VI but not II and V are selectively inhibited by nitric oxide
... Adenylyl cyclase (AC) (ATP pyrophos- phate-lyase, cycling; EC 4.6.1.1) catalyzes the synthesis of 3',5'-cyclic AMP (cAMP) from ATP. Several mammalian AC isoforms have been cloned (1-3). These isoforms are involved ...
7
Bordetella pertussis commits human dendritic cells to promote a Th1/Th17 response through the activity of adenylate cyclase toxin and MAPK-pathways.
... adenylate cyclase activity to BpCyaA2, recombinant CyaA was simultaneously administered and a genetically inactivated toxin, lacking adenylate cyclase enzymatic activity, CyaA*, was used as a ...
10
Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells.
... In addition, we show that the H 2 O 2 treatment of MDA-MD- 468 cells selectively decreases protein levels of PTBP1 and hnRNP A2/B1 splice factors identified as potential a 1 gene splicin[r] ...
9
Pituitary adenylate cyclase activating peptide deficient mice exhibit impaired thymic and extrathymic regulatory T cell proliferation during EAE.
... It has been shown that the nervous system and the immune system interact with each other during health and disease. In this regard, there is robust evidence that neurological mediators, including multiple ...
10
Pituitary adenylate cyclase activating peptide (PACAP) participates in adipogenesis by activating ERK signaling pathway.
... adenylate cyclase–activating polypeptide (PACAP) belongs to the secretin/glucagon/vasoactive intestinal peptide (VIP) ...adenylate cyclase activity and induces an increase of intracellular cyclic AMP ...
8