Insulin secretion
LPS-Enhanced Glucose-Stimulated Insulin Secretion Is Normalized by Resveratrol.
... homeostasis, insulin levels and ...induced insulin resistance as the glucose- stimulated insulin secretion during an oral glucose tolerance test was increased despite similar plasma glucose ...
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An extract from date seeds stimulates endogenous insulin secretion in streptozotocin-induced type I diabetic rats
... in insulin-treated diabetic rats (group ...endogenous insulin secretion in case of diabetic rats treated with date seed extract, which might be the cause of its hypoglycemic effect, and subsequently ...
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Geniposide regulates glucose-stimulated insulin secretion possibly through controlling glucose metabolism in INS-1 cells.
... the insulin release stimulated by glucose and other metabolizable insulin secretagogues was inhibited in proportion to the severity of pyruvate carboxylase knockdown ...regulates insulin ...
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Exercise at anaerobic threshold intensity and insulin secretion by isolated pancreatic islets of rats
... However, the studies carried out with experimental animals are questioned, since, in many cases, the intensity of the effort expe- rienced by the animals during the exercise was not evaluated. Therefore, the aim of this ...
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Changing Clinical Characteristics according to Insulin Resistance and Insulin Secretion in Newly Diagnosed Type 2 Diabetic Patients in Korea
... Unexpectedly, the ratio of subjects with insulin secretion disorders in our study was much lower than that of previous studies of Korean subjects. It is diicult to explain this discrep- ancy. Such ...
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A role for SPARC in the moderation of human insulin secretion.
... and secretion from adipose tissue is induced by ...of insulin secretion or in maintenance of beta-cell ...islet insulin secretory capacity, since both destruction and dedifferentiation of beta ...
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Development of the insulin secretion mechanism in fetal and neonatal rat pancreatic B-cells: response to glucose, K+, theophylline, and carbamylcholine
... the insulin release mech- anism in mammals occurs during the perina- tal period of ...stimulate insulin secretion in the late stages of the gestational period (2-4); in rats, this occurs at precisely ...
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MiR-184 regulates insulin secretion through repression of Slc25a22
... glucose-induced insulin secretion in the MIN6 islet β-cell ...(B) Insulin secretion ...glucose-induced insulin secretion in the MIN6 islet β-cell ...
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Insulin secretion, insulin sensitivity, and hepatic insulin extraction in first-degree relatives of type 2 diabetic patients
... measured insulin secretion, sensitivity to insulin, and hepatic insulin extraction in 48 healthy normal glucose-tolerant Brazilians, first-degree relatives of type 2 diabetic patients ...
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MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion.
... the insulin-like pathway; (b) mutations in misc-1 may positively affect insulin secretion, which in turn would compensate for the partial loss of DAF-2 function due to the hypomorphic mutation ...
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Association of acanthosis nigricans with race and metabolic disturbances in obese women
... fasting insulin levels in 25 obese women with AN in contrast to 9 without AN but this increase was not ...fasting insulin levels in 1412 obese children and showed a good correlation be- tween fasting ...
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A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets.
... In type 2 diabetes, overt hyperglycemia occurs when insufficient amounts of insulin are secreted [1]. A growing body of evidence implies mitochondrial dysfunction in the pathophys- iology of b-cell secretory ...
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Visfatin, glucose metabolism and vascular disease: a review of evidence
... to insulin secretion deficiency. This insulin secretion defect can be corrected by administer- ing nicotinamide mononucleotide (NMN), the product of visfatin on NAD ...with insulin when ...
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Food and the circadian activity of the hypothalamic-pituitary-adrenal axis
... in insulin secretion, which is inversely related to the circadian rhythm of cortisol ...the insulin response through changes in the pan- creatic beta cell sensitivity to glucose ...low insulin ...
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Arq Bras Endocrinol Metab vol.55 número4
... Beta cell dysfunction can be produced by prolon- ged exposure of these cells to elevated glucose (glu- cotoxicity) and lipid (lipotoxicity) levels, conditions often associated with DM2. The exact mechanisms by which ...
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Einstein (São Paulo) vol.12 número2
... induced by the interaction of nutrients in the lumen of the small intestine, and is calorie-dependent. When food reaches the bowel, L and K cells of the distal small intestine produce GLP-1 and glucose-dependent ...
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Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children.
... with insulin secretion or indices of insulin ...h insulin, but not with ...the insulin response to oral glucose was not different between carriers of the risk allele and wild ...
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Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume.
... Interestingly, common single nucleotide polymorphisms (SNPs) in EXT2 were associated with increased risk for the development of type 2 diabetes mellitus (DM2) [16]. Despite conflicting results [17–21], a recent ...
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Purification and of the biological effects of phospholipase A2 from sea anemone Bunodosoma caissarum
... Sea anemones contain a variety of biologically active substances. Bunodosoma caissarum is a sea anemone from the Cnidaria phylum, found only in Brazilian coastal waters. The aim of the present work was to study the ...
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Models for Incretin Research: From the Intestine to the Whole Body
... incretin secretion, might be the important pathophysiological mechanism of type 2 diabetes, especially in Caucasians ...ished secretion of incretin hormones could indicate decreased incretin ...to ...
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