Interleukin-1 receptor antagonist
A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist.
... The galactosaminogalactan (GAG) is a cell wall component of Aspergillus fumigatus that has potent anti-inflammatory effects in mice. However, the mechanisms responsible for the anti-inflammatory property of GAG remain to ...
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The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes.
... In order to understand the immunological activities of DH-PS, we investigated the profiles of cytokines and chemokines induced by DH-PS in mice. BALB/c mice (n = 3 for DH-PS and phosphate buffered saline (PBS) group) ...
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Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice.
... for 1 h at room temperature in a blocking buffer (Tris-HCl (pH ...diluted 1:500; for Cyclin D1, mouse monoclonal antibody diluted 1:500 (Santa Cruz Biotechnology, ...for 1 h at room ...
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Botulinum Toxin as a Novel Addition to Anti-Arthritis Armamentarium
... osteoarthritis. Interleukin-1 is the prototypical proinflammatory cytokine implicated in the pathogenesis of cartilage matrix ...for interleukin-1 in the pathogenesis of matrix loss in ...of ...
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Síndromes autoinflamatórias hereditárias na faixa etária pediátrica
... of interleukin-1 receptor antagonist; FCAS = familial cold autoinflammatory syndrome; FMF = familial Mediterranean fever; MKD = mevalonate kinase deficiency; MWS = Muckle-Wells syndrome; NOMID ...
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Keratinocyte growth factor, tumor necrosis factor-alpha and interleukin-1 beta gene expression in cultured fibroblasts and keratinocytes from burned patients
... IL-1 receptor antagonist to mice decreased the nociceptive response to an incisional wound, and reduced the production of multiple inlammatory mediators, including keratinocyte-derived chemokine (KC) ...
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Antiepileptic effect of the acylpolyaminetoxin JSTX-3 in human hippocampal CA1 neurons in vitro
... Results: Baseline autonomic activity (tone) was also measured by Heart rate variability (HRV) analysis. Autonomic functions were com- pared between 18 WC patients (mean age 23.67 ± 12.62, 11 males and 7 females) and 10 ...
368
Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics.
... appropriately. The rational design of molecules that disrupt PPIs is particularly challenging due to the large and structurally complex nature of the interfaces involved. A decisive strategy has been the identification ...
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Blockade of NK-1 receptors in the lateral commissural nucleus tractus solitarii of awake rats had no effect on the cardiovascular responses to chemoreflex activation
... ± 1 vs 108 ± 2 and 107 ± 3 vs 115 ± 4 mmHg, respectively) and no significant changes in heart rate (328 ± 11 vs 347 ± 15 and 332 ± 7 vs 349 ± 13 bpm, respectively) 2 min after ...NK-1 receptor ...
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Síndrome cardiorenal : diagnóstico e terapêuticas atuais
... As técnicas imagiológicas têm um papel adicional aos biomarcadores laboratoriais na SCR. São um complemento importante no diagnóstico da síndrome, ao amplificar e refinar a capacidade de quantificar a extensão do dano ...
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Roles of adrenergic α1 and dopamine D1 and D2 receptors in the mediation of the desynchronization effects of modafinil in a mouse EEG synchronization model.
... Cortical EEG activity was recorded in awake, freely moving mice contained in a plexiglass cage. Lightweight cables were connected to the implanted electrodes and cortical activity was recorded differentially against the ...
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Efeito da cafeína e dos receptores de adenosina na inflamação induzida por cobre em larvas de zebrafish (Danio rerio)
... important physiological functions such as modulation of neurotransmitter release, synaptic plasticity, neuroprotection to ischemic events, hypoxia and oxidative stress. Studies suggest that drugs that interfere in ...
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Avaliação do efeito do laser de Er:YAG no tratamento da doença periodontal crônica em humanos: análises clínica, imunológica e microbiológica
... After 30 days, even with significant improvement (p<0.05) in reduction of bleeding on probing for the different groups, no significant change was observed regarding levels of IL-1 . This suggests that the ...
139
A PTH/PTHrP receptor antagonist blocks the hypercalcemic response to estradiol-17b
... ing calcium and phosphate levels in fish, thus acting as a hypercal- cemic and hyperphosphatemic factor during periods of high calcium requirements, such as during vitellogenesis. Since parathyroid hor- mone ...
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Role of basic amino acids of the human angiotensin type 1 receptor in the binding of the non-peptide antagonist candesartan
... result from strong electrostatic interactions between their negatively-charged tetrazole and carboxyl groups with basic amino acid residues of the AT 1 -receptor. Further support for this hypothe- sis comes ...
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Avaliação do papel do sistema purinérgico e dopaminérgico no efeito antidepressivo promovido por MK-801 em peixe-zebra (Danio rerio)
... In order to analyze the duration of the antidepressant-like effect of MK-801, animals were exposed for 30 minutes to the lowest (5 µM) and highest(20 µM) concentrations tested in the previous experiment. It has been ...
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Rev. Bras. Psiquiatr. vol.31 número2
... The CB1 receptor antagonist rimonabant was approved for the treatment of obesity and soon removed from the market due to its psychiatric adverse effects. This drug has also been investigated for several ...
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CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice.
... More than half a century ago, Hans Selye, the father of the stress concept in biology, stated that ‘‘an intense psychic shock may also exert pronounced effects on the hair, e.g., graying and generalized loss of hair’’ ...
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Effects of the selective M1 muscarinic receptor antagonist dicyclomine on emotional memory
... Several studies have suggested the involvement of the cho- linergic system in learning and memory processes (Bartus et al. 1982; Deutsch 1971; Sen and Battacharya 1991). Anti- cholinergic drugs, such as the muscarinic ...
7
Rev. bras. farmacogn. vol.21 número4
... Abstract: The central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused ...
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