kinin receptors
Kinin receptors mediating the effect of bradykinin on gastric acid secretion
... of kinin ml) (Sigma), bacitracin (2 mg / ml) (Sigma) and sodium receptors involved in BK-induced acid secretion, the benaziprilat (2 mg / ml) (Ciba Geigy) was added to the mucosae were incubated in Ringer’s ...
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Balance between the two kinin receptors in the progression of experimental focal and segmental glomerulosclerosis in mice
... the kinin receptors, the animals were also treated with the B2RBK antagonist HOE-140 and the B1RBK antagonist ...both kinin receptors in an FSGS model and suggest a possible cross-talk between ...
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Regulation of the kinin receptors after induction of myocardial infarction: a mini-review
... the kinin receptors into B1R and B2R subtypes: ac- cording to hydrophobicity analysis, both re- ceptors belong to the superfamily of G-pro- tein-coupled cell-surface receptors (G-PCR), also called ...
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The Role of Kinin Receptors in Preventing Neuroinflammation and Its Clinical Severity during Experimental Autoimmune Encephalomyelitis in Mice
... that kinin can serve as a danger signal that triggers dendritic cell activation, driving T cell polarization, which means that kinins can modulate the immune response at the very beginning of the disease ...
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Activation of the kinin B1 receptor attenuates melanoma tumor growth and metastasis.
... To address the functional role of the B1 receptor in cellular events related to tumor progression, we first evaluated the effect of its agonist DABK in modulating cell migration. According to the in vitro wound healing ...
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Functional expression of kinin B1 and B2 receptors in mouse abdominal aorta
... ± 0.2 for DBK. The efficacy was 51 ± 2% for BK and 30 ± 1% for DBK when compared to 1 µM norepinephrine. The concentration-depend- ent responses of BK and DBK were markedly inhibited by the arachidonic acid inhibitor ...
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Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus
... kinin receptors and GAPDH using the Assays-by-Design Service (Applied Biosystems) to meet all Taqman TM design ...of Kinin B1 receptor (forward primer: 59-CCAGGGTTCGTCATCACT- ATCTG-39, reverse ...
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Role of vascular Kinin B-1 and B-2 receptors in endothelial nitric oxide metabolism
... lacking kinin receptors has allowed a better understanding of the physiological and pathological role of the kallikrein–kinin system in a wide range of biological events ...
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Molecular biology of the kallikrein-kinin system: from structure to function
... for kinin receptors B2 and B1 from different species were isolated and shown to encode G-protein-coupled receptors and the structure and pharmacology of the receptors were ...B1 ...
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Distinct kinin-induced functions are altered in circulating cells of young type 1 diabetic patients.
... lost their ability to generate sufficient levels of NO in response to BK stimulation and to support EC function. Presumably, additional deregulations in downstream molecular pathways (breakdown of oxidative defense, eNOS ...
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Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins
... by kinin receptors, has been shown to mitigate brain haemorrhages and vascular damage in a murine cerebral malaria model [40] and may modulate host haemodynamics during malarial ...
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Evidence that kinin B-2 receptor expression is upregulated by endothelial overexpression of B-1 receptors
... [28] Seguin T, Buleon M, Destrube M, Ranera MT, Couture R, Girolami JP, et al. Hemo- dynamic and renal involvement of B1 and B2 kinin receptors during the acute phase of endotoxin shock in mice. Int ...
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Myocardial chemokine expression and intensity of myocarditis in Chagas cardiomyopathy are controlled by polymorphisms in CXCL9 and CXCL10.
... T cells producing IFN-c and/or TNF-a were found in PBMC from CCC patients, as compared with ASY patients [26]. Previous studies from our group showed that gene expression levels of IFN-c-inducible chemokines CXCL9 and ...
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Tissue responsiveness to estradiol and genistein in the sea bass liver and scale
... estrogen receptors (ESR1, 2a and 2b) and membrane G-protein receptors (GPER and GPER-like) were different between liver and scales, which presumably explains the tissue-specific changes detected in ...
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Localization of NMDA receptors in the cerebral cortex: a schematic overview
... These receptors can monitor Glu re- lease by neighboring axon terminals (35,36) of thalamic (25) and corticocortical (70) ori- gin, as well as from axon collaterals of corti- cal Gluergic neurons (71), and ...
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J. bras. pneumol. vol.40 número2
... estrogen receptors and progesterone receptors were positive, and a diagnosis of benign metastasizing leiomyoma (BML) was made despite the atypical presentation, ...
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Exercício físico, receptores β-adrenérgicos e resposta vascular
... β-adrenergic receptors are present in a variety of ...β-adrenergic receptors promote positive inotropic and chronotropic response and ...β-adrenergic receptors as well as the cellular mechanisms ...
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Regulation of human umbilical artery contractility by different serotonin and histamine receptors
... + 64.6 mg). However, we also observed that L69 did not induce the same contractile effect in all the HUA rings. As shown in the Figure 2, there are 3 bars to represent the effect of this agonist. The second bar ...
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Adipocyte dysfunction in a mouse model of polycystic ovary syndrome (PCOS): evidence of adipocyte hypertrophy and tissue-specific inflammation.
... The relevance of current animal models of PCOS that involve the administration of androgens or other steroid hormones to the etiology of PCOS in humans is uncertain [32,33]. We have recently shown that specific genetic ...
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