Leukemia Cell
Leukemia Mediated Endothelial Cell Activation Modulates Leukemia Cell Susceptibility to Chemotherapy through a Positive Feedback Loop Mechanism.
... that leukemia cells themselves can activate ECs, and thus initiate this process, is indicative of a positive feedback loop scenario (Figure ...loop, leukemia cells produce conditions that activate ECs ...
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Potentiation of a novel palladium (II) complex lethality with bee venom on the human T-cell acute lymphoblastic leukemia cell line (MOLT-4)
... Background: Although honeybee venom (BV) has been reported to induce apoptosis in different types of cancerous cells, its synergistic effects with customary anti-cancer drugs remain largely unknown. In the present study, ...
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The effects of anti-leukemia chemotherapy on LKB1-AMPK pathway functioning in acute myeloid leukemia cell lines
... myeloid leukemia (AML) therapies present poor outcomes among old patients, it becomes crucial to elucidate the mechanisms underlying AML cell´s resistance/susceptibility to conventional chemotherapy in ...
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Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis
... V617F cell line, but not in U937 JAK2 wild-type leukemia cell lines, IRS2 was constitutively phosphorylated and associated with ...reduced cell viability and increased ...reduced cell ...
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J. Braz. Chem. Soc. vol.28 número2
... and aminoguanidine hydrochloride in the presence of KOH, furnishing a series of twelve 3-(thiophen-2-yl)-4,5-dihydro- 1H-pyrazole-1-carboximidamides in short reaction times (15-35 min) and good yields (62-95%). All ...
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Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames test
... tumor cell lines, especially human leukemia cell lines, such as HL-60, K562, Jurkat and Molt-4, as well antifungal, antileishmanial, antitry- panosomal activities, anti-platelet aggregation, ...
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CD20 antibody primes B lymphocytes for type I interferon production.
... Innate immunity is important to control viral infection, but over-activation of the innate immunity may lead to autoimmune diseases. IFNs are a key component of host innate immunity. CD20 antibodies represent a class of ...
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Characterization of the apoptotic response induced by the cyanine dye D112: a potentially selective anti-cancer compound.
... cancer cell line in comparison to a non-transformed cell ...T-cell leukemia cell line Jurkat showed caspase activation, mitochondrial depolarization, and phosphatidylserine ...
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Rev. bras. farmacogn. vol.27 número5
... the leukemia cell line (K-562, GI 50 = ...endothelial cell proliferation, probably by promoting membrane cell depolarization, suggesting a potential antiangio- genic effect (Siekmann et ...
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NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.
... dilution, Cell Signaling, Danvers, MA), activated caspase 3 (1:50 dilution, Abcam, Cambridge, MA), as well as NOTCH1 intracellular domain (1:50 dilution, ICN1, Epitomics, Burlingame, CA) to examine expression ...
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Rev. Soc. Bras. Med. Trop. vol.35 número3
... T-cell Leukemia and Lymphoma-ATLL), to a characteristic uveitis and a neurological chronic disease, Tropical Spastic Paraparesis or HTLV-I Associated Myelopathy ...
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KIT D816V Positive Acute Mast Cell Leukemia Associated with Normal Karyotype Acute Myeloid Leukemia
... Copyright © 2018 Marta Lopes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
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Equitoxic doses of 5-azacytidine and 5-aza-2'deoxycytidine induce diverse immediate and overlapping heritable changes in the transcriptome.
... stem cell transplantation have shown a survival benefit in MDS patients, however this regimen is only feasible in the smaller fraction of younger MDS ...myeloid leukemia (AML) [4,5,6,7,8,9], however two ...
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Rev. Bras. Hematol. Hemoter. vol.38 número2
... lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and Burkitt’s ...lymphocytic leukemia patients were classified as low ...
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Rev. Bras. Hematol. Hemoter. vol.37 número5
... 15. Rossi D, Sozzi E, Puma A, De Paoli L, Rasi S, Spina V, et al. The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by ...
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Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.
... reduction, an occurrence normally prevented by Nampt [8,10,12,16]. The involvement of other enzymatic activities/metabolic processes in enhancing T cell susceptibility to FK866 is suggested by the fact that PARP ...
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Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death.
... confer cell-adhesion-mediated-drug-resistance (CAM- DR) that pose therapeutic obstacles in several neoplasms including MM ...with cell adhesion has been a desired target for increasing cytotoxicty of ...
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Dissecting the cellular and molecular mechanisms of IL-7-mediated leukemia T-cell survival proliferation and cell growth
... promoted cell death ...of cell metabolism and are in line with our expression data on rapid Bcl-2 upregulation by IL-7 in T-ALL ...promote cell cycle progression via Cdk-1 activation ...
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Acute Lymphoblastic Leukemia in a Young Adult Presenting as Hepatitis and Acute Kidney Injury
... blood cell counts, uric acid levels, and lac- tate dehydrogenase levels, suggesting tumor infiltration as the underlying ...blood cell count, older age, bulky disease, and T-cell ...
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J. Bras. Patol. Med. Lab. vol.49 número1
... T cell leukemia virus type I and neurologic disease: events in bone marrow, peripheral blood, and central nervous system during normal immune surveillance and ...J Cell Physiol, ...Thymusderived ...
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