MEK/ERK
Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells.
... We next asked whether the lack of TCR internalization upon HMB-PP treatment could be associated with sustained activation of cd T-cells. We tested the capacity of cells that had been treated for 2 days with either HMB-PP ...
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AS-703026 Inhibits LPS-Induced TNFα Production through MEK/ERK Dependent and Independent Mechanisms.
... novel MEK/ERK inhibitor, suppressed LPS-induced TNFα mRNA expression and protein secretion in RAW ...LPS-induced MEK/ ERK activation in above ...restoring ERK activation in ...
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TGF-β inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathways.
... We examined whether TIEG1 restoration in vitro in osteoclast precursors could restore the WT phenotype of TIEG1 2/2 cells. We infected precursors from TIEG1 2/2 mice with a mouse adenoviral TIEG1 (AdTIEG1) expression ...
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Evodiamine synergizes with doxorubicin in the treatment of chemoresistant human breast cancer without inhibiting P-glycoprotein.
... Ras/ MEK/ERK pathway and IAP expression may sensitize human cancer cells to ...Ras/MEK/ ERK pathway and IAP expression, whereas the combination of DOX and EVO led to the decreased expression ...
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PARTICIPAÇÃO DO ATIVADOR DO PLASMINOGÊNIO DO TIPO UROQUINASE NA MIGRAÇÃO DE CÉLULAS INFLAMATÓRIAS
... Plasminogen (plg) is a zymogen that is cleaved to plasmin (pla) by the tissue- type (tPA) or urokinase-type (uPA) activator. The classical function of the plg/pla system is the dissolution of fibrin clots, but it has ...
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Ras and Rac1, Frequently Mutated in Melanomas, Are Activated by Superoxide Anion, Modulate Dnmt1 Level and Are Causally Related to Melanocyte Malignant Transformation
... and MEK-ERK ...to MEK-ERK signaling pathway, we observed its activation during melan-a anchorage blockade (Figure 4A) and its inhibition impaired the increase both in superoxide (Figure 5A and ...
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Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting.
... Understanding the signaling events necessary for the transform- ing activities of Ras is crucial for the development of novel Ras- targeted therapies. Emerging studies have begun to explore the therapeutic values of ...
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Heterologous expression of human KRASwt cDNA in Saccharomyces cerevisiae and its mutants from the Ras signalling pathway and phenotype screening
... Raf-mitogen-activated kinase (MAPK) and PI3K the best characterize Ras-controlled effectors (Fig. The RAS/Raf/MEK/ERK signalling pathway has been shown to play key role in [r] ...
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A-RAF kinase functions in ARF6 regulated endocytic membrane traffic.
... Model of A-RAF function in regulation of endocytosis The novel findings on the A-RAF localization and the interaction with ARF6 have led to a new model of A-RAF function shown in Figure 9. Stimulation of growth factor ...
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Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models.
... Although targeted therapy has become a mainstream approach for cancer treatment, the clinical development of targeted agents in pancreatic cancer has not been successful. Because of the high frequency of KRAS mutations ...
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Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics.
... of MEK and ERK promote path- way activation through release of negative feedback, consistent Figure ...with Mek/Erk inhibition has an additive effect on MAPK ...of Mek-i A and constant ...
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β-lapachone significantly increases the effect of ionizing radiation to cause mitochondrial apoptosis via JNK activation in cancer cells.
... (SP600125), MEK/ERK (PD98059), p38 MAPK (SB203580), caspases (z-VAD-fmk), protease (MG132) and ER stress (Salubrinal) were purchased from Calbiochem (San Diego, ...
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Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth.
... Berberine (BBR), an isoquinoline derivative alkaloid isolated from Chinese herbs, has a long history of uses for the treatment of multiple diseases, including cancers. However, the precise mechanisms of actions of BBR in ...
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Qualitative Modelling of Quasi-homogeneous Effects in ERK and STAT Interaction Dynamics
... of ERK-protein concentrations are analyzed in terms of corresponding reaction-diffusion ...predicted ERK and STAT pathway instability can be interpreted as traveling wave propagation of molecular ...
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Role of Fos-related antigen 1 in the progression and prognosis of ductal breast carcinoma
... We also observed a low frequency of HER-2 expression in invasive disease as compared to the DCIS cases, confirming previous reports. 22–26 Like that of HER-2, Fra-1 expression may be characteristic of tumours at a ...
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Scattering of MCF7 cells by heregulin ß-1 depends on the MEK and p38 MAP kinase pathway.
... 3. MEK inhibitors can block ...collagen. MEK inhibitor PD98059 (10 mM) was added to the cultures on some ...of MEK, the disappearance of F-actin from cell–cell contact was ...
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Implementation of fuzzy system using different voltages of OTA for JNK pathway leading to cell survival/ death
... Upon ligand-binding receptors homo-dimerise or hetero-dimerise triggering tyrosine trans- phosphorylation of the receptor sub-units. These tyrosine phosphorylated sites allow proteins to bind through their Src homology 2 ...
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J. Bras. Nefrol. vol.38 número2
... Couser, Timur Erk, Julie R Ingelfinger, Kamyar Kalantar-Zadeh, Charles Kernahan, Charlotte Osafo, Miguel C.. Dados da DRC do NAPRTCS, Dados Italianos e Dados Belgas.[r] ...
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Rev. paul. pediatr. vol.34 número2
... Dados sobre doenc ¸a renal crônica foram obtidos do estudo North-American Pediatric Renal Trials and Collaborative Studies, do registro italiano e do registro belga.. Couser, Timur Erk, [r] ...
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The idea of an educated public in the Macintyre’s critique of the enlightenment
... Pristanak na zajedničke standarde za procenu teza i argumenata, kao i na formu racionalnog dokazivanja iz kojeg ovi standardi izvode svoj autoritet jeste ono što, kako ovde navodi Mek[r] ...
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