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Metabolic networks

Uniform sampling of steady states in metabolic networks: heterogeneous scales and rounding.

Uniform sampling of steady states in metabolic networks: heterogeneous scales and rounding.

... in metabolic networks [15–17] but it has the drawback that its non-markovian nature doesn’t guarantee the convergence to an uniform ...a metabolic network can show very heteroge- neous scales on ...

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Context-specific metabolic networks are consistent with experiments.

Context-specific metabolic networks are consistent with experiments.

... Knowledge of transcriptional regulation of metabolism comes from different sources. At a low level, from the bottom up, some of the regulatory proteins that control the transcription of sets of metabolic genes are ...

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Analysis of minimal metabolic networks through whole-cell in silico modelling of prokaryotes

Analysis of minimal metabolic networks through whole-cell in silico modelling of prokaryotes

... to metabolic networks (chorismate synthase) appeared much earlier than the divergence of prokaryotes and eukaryotes, close to LUCA’s ...prokaryotic networks; the evolution of these enzymes might have ...

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Attractor metabolic networks.

Attractor metabolic networks.

... on metabolic rhythms have contributed to a better understanding of the functionality of the self-organized multienzymatic subsystems (the nodes of the dissipative metabolic ...each metabolic ...

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A scalable algorithm to explore the Gibbs energy landscape of genome-scale metabolic networks.

A scalable algorithm to explore the Gibbs energy landscape of genome-scale metabolic networks.

... the metabolic capabilities of a cell are inferred from the overall configuration space compatible with minimal physico-chemical constraints describing the non-equilibrium steady state of the underlying reaction ...

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Gender differences of brain glucose metabolic networks revealed by FDG-PET: evidence from a large cohort of 400 young adults.

Gender differences of brain glucose metabolic networks revealed by FDG-PET: evidence from a large cohort of 400 young adults.

... of metabolic connectivity in the human brain: autocorrelation only, correlation with contralatral homologous regions, and correlation with remote ...glucose metabolic networks of both genders, and ...

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Enumeration of smallest intervention strategies in genome-scale metabolic networks.

Enumeration of smallest intervention strategies in genome-scale metabolic networks.

... of metabolic network modeling is the rational redesign of biochemical networks to optimize the production of certain compounds by cellular ...genome-scale metabolic networks are still ...

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Why excluding H2O from metabolic networks?

Why excluding H2O from metabolic networks?

... biologically meaningful transformations generally, and they might bring some unrealistic biochemical pathways. Later, Ma and Zeng (2003) addressed the problem and reported their metabolic network models in which ...

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A systems approach to predict oncometabolites via context-specific genome-scale metabolic networks.

A systems approach to predict oncometabolites via context-specific genome-scale metabolic networks.

... in metabolic enzymes, we determined the total number of mutations in enzymatic genes across nine cancer ...The metabolic genes were identified from the global human metabolic network Recon 2 ...20 ...

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Differential producibility analysis (DPA) of transcriptomic data with metabolic networks: deconstructing the metabolic response of M. tuberculosis.

Differential producibility analysis (DPA) of transcriptomic data with metabolic networks: deconstructing the metabolic response of M. tuberculosis.

... internal metabolic flux distribution and the transcriptional profile of genes encoding metabolic ...scale metabolic reaction network and at the same time maximize the number of active ...

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Toward a systems-level understanding of gene regulatory, protein interaction, and metabolic networks in cyanobacteria

Toward a systems-level understanding of gene regulatory, protein interaction, and metabolic networks in cyanobacteria

... central metabolic pathways, under different light and media conditions ...recent metabolic mod- els (Nogales et ...759 metabolic reactions, involving 601 ...these networks, and at the same ...

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Exploring chemical conversions in metabolic networks by tracing atoms transitions

Exploring chemical conversions in metabolic networks by tracing atoms transitions

... the metabolic data for this organism was experimentally verified and so, the current reconstructions of ...coli metabolic network are the best representation of the metabolic capabilities of this ...

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Design of optimally constructed metabolic networks of minimal functionality.

Design of optimally constructed metabolic networks of minimal functionality.

... Microorganisms are increasingly used as cell factories to produce a multitude of chemicals and promise great potential for many future applications [1–4]. Microorganisms provide many benefits as production hosts: (i) ...

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STRUCTURAL AND FUNCTIONAL ANALYSIS OF GIANT STRONG COMPONENT OF BACILLUS THURINGIENSIS METABOLIC NETWORK

STRUCTURAL AND FUNCTIONAL ANALYSIS OF GIANT STRONG COMPONENT OF BACILLUS THURINGIENSIS METABOLIC NETWORK

... the metabolic network reconstructed is represented by metabolite ...whole metabolic networks, we extracted the most important part giant strong component (GSC) and analyzed its global structural ...

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Polaromonas sp. strain JS666: Analysis of cDCE

Polaromonas sp. strain JS666: Analysis of cDCE

... genome-scale metabolic network reconstruction the first step on the debugging mode is the identification of the metabolic gaps present in the draft ...A metabolic/pathway gap can be seen as a hole in ...

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Mestre em Engenharia Biológica

Mestre em Engenharia Biológica

... intricate networks of a large number of genes, proteins, and ...larger networks comprising the environment as well as other cells or organisms ...the metabolic networks of prokaryotic species ...

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RegnANN: Reverse Engineering Gene Networks using Artificial Neural Networks.

RegnANN: Reverse Engineering Gene Networks using Artificial Neural Networks.

... Early network inference models were based on the analysis of the correlation coefficients [6,7] between expression patterns of all pairs of genes to infer co-expression networks. On the basis that correlation ...

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Computational tools for pathway optimization towards metabolic engineering applications

Computational tools for pathway optimization towards metabolic engineering applications

... The determination of specific features is not straight forward, specially when these vary a lot between different metabolic databases. However, the basic requirements of each individual entity type is defined in ...

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Efeito do CPAP no estresse oxidativo e na qualidade de vida em adultos e idosos com síndrome da apnéia obstrutiva do sono

Efeito do CPAP no estresse oxidativo e na qualidade de vida em adultos e idosos com síndrome da apnéia obstrutiva do sono

... Oxidative stress and metabolic changes after continuous positive airway pressure treatment according to previous metabolic disorders in sleep apnea-hypopnea syndrome pat[r] ...

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Achieving Universal Access to Broadband

Achieving Universal Access to Broadband

... generation networks can be of- fered by use of a wide range of different network access technologies each having their own specif- ic comparative advantages with respect to tech- nical capabilities and economic ...

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