Microglia activation
Pyrroloquinoline quinone (PQQ) inhibits lipopolysaccharide induced inflammation in part via downregulated NF-κB and p38/JNK activation in microglial and attenuates microglia activation in lipopolysaccharide treatment mice.
... Therapeutic strategies designed to inhibit the activation of microglia may lead to significant advancement in the treatment of most neurodegenerative diseases. Pyrroloquinoline quinone (PQQ) is a naturally ...
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ALS pathogenesis: role of motor neuron-derived exosomes in microglia activation and dysfunction
... of microglia phagocytic ability, acute release of NO, MMP-2 and MMP-9, and interleukin (IL)-1β and tumor necrosis factor (TNF)-α expression, together with lasting NF-κB activation and delayed increase of ...
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Notch-1 signaling regulates microglia activation via NF-κB pathway after hypoxic exposure in vivo and in vitro.
... activated microglia is suggested to play a pivotal role in the pathogenesis of hypoxic brain injury; however, the underlying mechanism of microglia activation remains ...orchestrates microglia ...
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Intrathecal injection of spironolactone attenuates radicular pain by inhibition of spinal microglia activation in a rat model.
... glial activation, inflammatory cytokine release as well as the expression and phosphorylation of NMDA receptor affect or facilitate neuronal plasticity through interactions with mineralocorticoid receptor and play ...
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Histamine modulates nitric oxide release by microglia and dopaminergic neuronal survival
... the activation of the microglia, such as oxidative stress and mitochondrial dysfunction may be involved in neuronal cell death (Doble, 1999; Andersen, 2004; Witte et ...between microglia ...
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Phosphatidylinositol 3-Kinase γ is required for the development of experimental cerebral malaria.
... Slides were then washed and blocked with PBS containing 5% (w/v) nonfat dry milk and 0.1% Tween-20. All incubations were performed in a wet chamber. Brain sections were then incubat- ed overnight at 4°C with rabbit ...
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Avaliação da expressão post-mortem das citocinas IL-1β, TNF-α e IL-6 em cérebro de Mus musculus submetidos à dor
... The nociception-mediated pain status is typically associated with a tissue injury that produces an acute electrophysiological discharge at the nerve terminals and a response to C-polymodal nerve fibers associated with ...
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Dietary vitamin D3 supplements reduce demyelination in the cuprizone model.
... loss, microglia/ macrophage activation, and lymphocyte infiltration after six weeks of cuprizone exposure, and two weeks after discontinuation of cuprizone ...attenuated microglia activation ...
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Treatment with the antipsychotic agent, risperidone, reduces disease severity in experimental autoimmune encephalomyelitis.
... on microglia activation and cytokine expres- sion; for example, Kato et ...monocyte activation within an inflammatory environment towards an anti-inflammatory phenotype can inhibit EAE disease induc- ...
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Orientador: Dora Maria Tuna de Oliveira Brites Investigadora Coordenadora e Professora Catedrática Convidada Co-orientador: Ana Rita Mendonça Vaz Doutora Faculdade de Farmácia, Universidade de Lisboa
... with microglia activation (Neusch et al., 2007). Microglia expressing mutant SOD1 change from their normal surveying state to an activated one, migrate to initial sites of injury and trigger high ...
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CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality.
... mononuclear cells isolated from naı¨ve murine brain. (C) Viral antigen NS3 (red; cells counterstained with Hoechst (blue)) was detected in JEV- infected microglia or mixed glia (m.o.i. = 5) in the presence of ...
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VEGF receptor blockade markedly reduces retinal microglia/macrophage infiltration into laser-induced CNV.
... At 14 days after laser, the number of Iba1(+) cells and the immunoreactivity were evidently increased in PBS control, compared to 3 days after laser (Fig. 7). These cells were distributed throughout the retina from ...
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Contribuition of different cellular subsets to the adenosine A2a receptor overexpression in the rat brain
... Adenosine is a purine nucleoside produced through the catabolism of ATP by ecto-nucleotidases. Ubiquitously present in all cell types, its ability to modulate cell metabolism is widely described, namely in Central ...
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Biomarkers of inflammation and axonal degeneration/damage in patients with newly diagnosed multiple sclerosis: contributions of the soluble CD163 CSF/serum ratio to a biomarker panel.
... For OPN, we found that patients with CIS had significantly elevated GMs of OPN in serum as compared with SC, as was also the case in the age adjusted linear regression model (table 6). Furthermore, the GM levels in CIS ...
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Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells.
... when microglia were included in the co-culture of SY cells with ...study microglia- induced gene expression changes in the SY cells, transwell inserts were incorporated into the culture system providing ...
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Entry, Dispersion and Differentiation of Microglia in the Developing Central Nervous System
... ameboid microglia during their mi- gration appears to be a widespread event that con- tributes to an increase in the number and dispersion of microglial precursors through the CNS during normal ...
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Exploring deregulated signals involved in Motor neuron-Microglia cross-talk in ALS
... and microglia, we intended to further explore which signaling pathways were compromised by the presence of ...keep microglia in a quiescent- like state, preventing them from over-activation and its ...
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Activation of phospholipase PLA
... Key words: cellular defense, castor bean, plant signaling, phospholipase A 2 , Ricinus communis.. Com o objetivo de avaliar a resposta de defesa da mamona ( Ricinus communis ) contra p[r] ...
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Citocinas e dor
... Interleukin-1β and TNFα, the irst cytokines to be formed after tissue damage or infection, affect directly speciic recep- tors on sensorial neurons, leading to the “cascade” synthesis of other effectors, such as other ...
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Facial mimicry in its social setting
... Hess and Bourgeois (2010), using EMG measurement of two participants concurrently, found that in such interactions, women smiled more than men, and both genders showed more Duchenne smiles than polite smiles. The latter ...
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