Motor neuron
Sialorrhoea: How to Manage a Frequent Complication of Motor Neuron Disease
... Sialorrhoea, the unintentional loss of saliva through the mouth, is the frequent complication of neurological disorders afecting strength or coordination of oropharyngeal muscles, such as motor neuron ...
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Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord.
... by motor neurons is limited, it has recently been shown that motor neurons not only respond to neurotrophic cues but also express and secrete growth factors ...promotes motor neuron survival ...
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Is the risk of motor neuron disease increased or decreased after cancer? An Australian case-control study.
... Cancer appears to be inversely associated with both Alzheimer’s and Parkinson’s disease. The relationship between cancer and sporadic motor neuron disease (SMND), however, remains uncertain. Most previous ...
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Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy.
... positive motor neurons, Tuj1 positive neurons, and GFAP positive astrocytes ...HB9 motor neuron-specific promoter in iPSCs in conjunction with co-culture assays will address this ...
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Exploring deregulated signals involved in Motor neuron-Microglia cross-talk in ALS
... of motor neuron degeneration in ALS, one of the most recent proposals to therapy concerning neurodegenerative disorders is replacement of microglial cells (Cartier et ...protect motor neurons in ALS ...
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Vitamin B12 deficiency mimicking neuroimaging features of motor neuron disease
... A 45-year-old man presented with 2-month-history of progressive gait disturbances and behavioral changes. Exa- mination showed vibration sense compromise and pyrami- dal signs of release. Blood test revealed low serum ...
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Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis.
... distal motor axons are amongst the earliest pathological changes in the pathogenesis of ALS, followed by a ‘‘dying back’’ process [73,54], some studies [74] have questioned the origin of ALS and proposed that ...
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Linear associations between clinically assessed upper motor neuron disease and diffusion tensor imaging metrics in amyotrophic lateral sclerosis.
... There were several other limitations to our study. While greater than others, the number of subjects in our study, 34, was not large. If multicenter trials are to be performed evaluating DTI as a biomarker in ALS, the ...
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SCA2 presenting as an ataxia-parkinsonism-motor neuron disease syndrome
... his report highlights that unusual phenotypes such as an ataxia-parkinsonism-motor neuron disease syn- drome may be found in SCA 2 individuals. his raises several questions such as whether or not patients ...
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Genetic overlap between apparently sporadic motor neuron diseases.
... Motor neuron diseases (MNDs) are a heterogeneous group of disorders characterized by muscle weakness and/or spasticity due to degeneration of motor ...lower motor neurons (LMNs) ...
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ALS pathogenesis: role of motor neuron-derived exosomes in microglia activation and dysfunction
... from motor neuron (MN)-like NSC-34 cells overexpressing human superoxide dismutase 1 mutated in G93A (mSOD1), was suggested to be implicated in cell-to-cell transfer of mSOD1 ...
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Arq. NeuroPsiquiatr. vol.73 número4
... Afonso C. P. Liberato et al. Low signal intensity of motor cortex in SWI sequence: a radiological marker for motor neuron disease? Figure 2. Axial SWI MRI (A, B and C) in a 81 year-old man with ALS ...
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Arq. NeuroPsiquiatr. vol.68 número2
... sis (ALS), therefore we would not be able to report their disease especiically as ALS, but only as a motor neuron disorder. In our paper, we considered as ALS those pa- tients who had not only clinical, but ...
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Arq. NeuroPsiquiatr. vol.75 número4
... In the early hours, the most important element to guide the diagnosis is the neurological evaluation. Diseases of the peripheral nerves afect distal muscles irst, and myopathies or lower motor neuron ...
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Transplantation of Xenopus laevis tissues to determine the ability of motor neurons to acquire a novel target.
... a motor neuron to reroute to target a novel tissue that is transplanted into its trajectory; however, the nervous system is not completely plastic and not every motor neuron can interact with ...
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Action potential energy efficiency varies among neuron types in vertebrates and invertebrates.
... each neuron is using its combination of channels to produce its particular ...leg motor neuron axon, CA [9], a mouse (Mus musculus) fast spiking GABAergic cortical interneuron, MFS [10], a worker ...
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Facial grimacing as a clue for the diagnosis of GM1 type 3 gangliosidosis
... his report highlights that unusual phenotypes such as an ataxia-parkinsonism-motor neuron disease syn- drome may be found in SCA 2 individuals. his raises several questions such as whether or not patients ...
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Dement. neuropsychol. vol.8 número1
... on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federa- tion of Neurology Research Group on Neuromuscular Diseases and the El Escorial “Clinical limits of amyotrophic lateral sclerosis” ...
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Arq. NeuroPsiquiatr. vol.73 número12 X anp X20150161
... FTD-ALS type 2 (MIM #615911) represents a rare au- tosomal dominant form of familial ALS with frontotem- poral dementia, resulting from heterozygous mutations in the CHCHD10 gene (Coiled-coil-helix-coiled-coil-helix ...
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