MTHFR gene
Strong association of 677 C>T substitution in the MTHFR gene with male infertility--a study on an indian population and a meta-analysis.
... methylation. MTHFR reduces methylenetetrahy- drofolate to methyltetrahydrofolate which then donates methyl group to homocysteine to form ...[3]. MTHFR activity is higher in adult testis than other organs in ...
14
Arq. Bras. Cardiol. vol.88 número2 en a06v88n2
... Results: Significant differences were observed in mean homocysteine levels between the control and the severe atheromatosis groups (p < 0.001). No significant differences were observed among the other groups. The ...
6
The effect of 677C>T and 1298A>C MTHFR polymorphisms on sulfasalazine treatment outcome in rheumatoid arthritis
... 1298A>C MTHFR polymorphisms and sulfasalazine efficacy for the treatment of RA, a total of 117 RA patients treated with sulfasalazine (1 g daily; duration of treatment 17 ± 5 months) were ...the MTHFR ...
5
Folate metabolism gene 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with ADHD in myelomeningocele patients.
... of MTHFR SNPs were evaluated for deviation from Hardy-Weinberg equilibrium (HWE) expectations (p ...the MTHFR gene that was significantly associated with the ADHD phenotype (see Table ...the ...
7
Rev. Bras. Hematol. Hemoter. vol.32 número6
... Avaliação: A RBHH publica os resumos e abstracts de teses da área apresentados em entidades que tenham programas de pós-graduação reconhecidos pelo MEC/Capes e considera a obtenção do título suficiente para sua ...
2
Arq. NeuroPsiquiatr. vol.64 número4
... in MTHFR gene and Alzheimer´s disease (AD) ...for MTHFR by ...A1298C MTHFR polymorphisms distributions were found between patients and ...A1298C MTHFR polymorphisms contributed to ...
5
Association of blood lead levels with methylenetetrahydrofolate reductase polymorphisms among Chinese pregnant women in Wuhan city.
... that MTHFR gene polymorphisms are related to bone mineral loss, which is an important endogenous lead source during pregnancy, we assumed that MTHFR gene polymorphisms are potentially related ...
13
The relationship between of ACE ID and the MTHFR C677T polymorphisms in the pathophysiology of type 2 diabetes mellitus in a population of Brazilian obese patients
... (ACE) gene insertion/deletion (I/D) and methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphisms in obese patients with and without type 2 diabetes mellitus ...and MTHFR ...
6
Prevalence of the polymorphism MTHFR A1298C and not MTHFR C677T is related to chromosomal aneuploidy in Brazilian Turner Syndrome patients
... the MTHFR gene. Polymorphism MTHFR A1298C was more frequent among the Turner Syndrome patients in the present study and, although it has less im- pact on the enzyme activity than polymorphism ...
9
Braz. j. . vol.82 número5
... MTHFR gene encodes the methylenetetrahydrofolate reductase enzyme, that is important for intracellu- lar folate homeostasis and the irreversible conversion of 5,10-methylenetetrahydrofolate (5,10-MTHF) into ...
9
Mutações no gene da metilenotetrahidrofolato redutase e síndrome de Down.
... (MTHFR) gene may be mater- nal risk factors for DS. Frequency of the MTHFR 677 (C→T) and 1298 (A→C) mutations was eval- uated in 36 mothers of children with DS and in 200 ...the MTHFR 677 ...
3
Frequência genotípica em amostras de MTHFR para o polimorfismo C677T em pacientes da cidade de Curitiba-PR.
... Plasma homocysteine, associated with a mutation in the methyltetrahydrofolate reductase (MTHFR) gene, is regarded as a risk factor for coronary disease. The aim of this study was to determine the number of ...
4
The MTR A2756G polymorphism is associated with an increase of plasma homocysteine concentration in Brazilian individuals with Down syndrome
... the MTHFR gene was detected using primer sequences described by Frosst et ...the MTHFR gene as positive control of gene amplification ...this gene, which is located on chromosome ...
7
Methylenetetrahydrofolate Reductase Polymorphisms at Familial Bladder Cancer: Case Report
... the MTHFR C677T and A1298C polymorphisms and bladder cancer risk, it has been observed that the variant genotype MTHFR 677TT was associated with an increased risk of bladder cancer, com- pared with the ...
3
Association between MTHFR polymorphisms and acute myeloid leukemia risk: a meta-analysis.
... the gene expression and DNA ...(MTHFR) gene is found at the end of the short arm of chromosome one at locus ...this gene is approximately ...of MTHFR locus in human is a ...
8
Geographical and Ethnic Distributions of the MTHFR C677T, A1298C and MTRR A66G Gene Polymorphisms in Chinese Populations: A Meta-Analysis.
... enzyme MTHFR catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyletetrahydrofolate, which is the carbon donor for the methylation of homocysteine to methionine ...the MTHFR gene ...
20
Análise do polimorfismo C677T da metilenotetraidrofolato redutase em pacientes com episódio de trombose venosa
... Introduction: Venous thromboembolism (VTE) is a multigenic and multifactor disease and main clinical presentations include deep venous thrombosis and pulmonary thromboembolism. More than 60% of VTE cases are related to ...
69
UNIVERSIDADE FEDERAL DO PARA CENTRO DE CIÊNCIAS BIOLÓGICAS PROGRAMA DE PÓS-GRADUAÇÃO BIOLOGIA DE AGENTES INFECCIOSOS E PARASITÁRIOS POLIMORFISMOS NO GENE MTHFR - METILENOTETRAHIDROFOLATO
... the MTHFR gene (C677T and A1298C) might be maternal risk factors for Down ...the MTHFR gene (C677T and A1298C) and a possible association of them, as maternal risk factors for Down Syndrome, ...
95
Preconception Screening for Gene Polymorphisms Associated with Thrombophilia and Hyperhomocysteinemia Risk in Healthy Young Women
... and MTHFR gene polymorphisms was observed in the healthy planned-pregnancy young women (MTRR 66G/G - ...31.5%, MTHFR 1298C/C - 11.5%, and MTHFR 677T/T - ...
3
Association of homocysteine and methylene tetrahydrofolate reductase (MTHFR C677T) gene polymorphism with coronary artery disease (CAD) in the population of North India
... inson et al., 1995; Hofmann et al., 2001; Andreassi et al., 2003). Hcy, an amino acid derived from protein catabolism, is present in the plasma in several forms, with the greatest proportion (70%) bound to albumin ...
5