Nuclear localization signal
SeqNLS: nuclear localization signal prediction based on frequent pattern mining and linear motif scoring.
... A nuclear localization signal is a protein peptide bound to carrier proteins for trafficking nuclear proteins into the ...for nuclear localization, identification of NLSs can ...
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Identification of a novel nuclear localization signal sequence in Chlamydia trachomatis-secreted hypothetical protein CT311.
... contained nuclear localization ...the nuclear localization signal sequence (NLS) of ...GFP signal was further semi-quantita- tively measured and % of GFP signal in the ...
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The LSD1-type zinc finger motifs of Pisum sativa LSD1 are a novel nuclear localization signal and interact with importin alpha.
... The four zinc-chelating cysteine residues are involved in binding to zinc ion, and thus are essential for tertiary structure of LSD1- Figure 2. The NLS of PsLSD1 is located in the three LSD1-type zinc finger motifs. (A) ...
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A novel bipartite nuclear localization signal guides BPM1 protein to nucleolus suggesting its Cullin3 independent function.
... and are critical components in the ubiquitin dependant protein proteolysis by the 26 S proteasome complex. The protein family contains a BTB/POZ domain located at the C-terminus and a Meprin and TRAF Homology (MATH) ...
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Structure of Importin-α from a Filamentous Fungus in Complex with a Classical Nuclear Localization Signal.
... putative nuclear localization signals (NLSs), either monopartite or bipartite, suggesting that they can be transported into the nucleus via the classical nuclear pathway [3], which is mediated by ...
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Enhancement of non-viral transfection efficiency with nuclear localization signal peptides
... of nuclear membrane (Boulanger et ...improve nuclear delivery of DNA and, thus, increase gene expression (Boulanger et ...the nuclear transport of DNA (Opanasopit et ...
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Sox11 Reduces Caspase-6 Cleavage and Activity.
... The apoptotic cascade is an orchestrated event, whose final stages are mediated by effec- tor caspases. Regulatory binding proteins have been identified for caspases such as cas- pase-3, -7, -8, and -9. Many of these ...
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IL-15 deficient tax mice reveal a role for IL-1α in tumor immunity.
... a nuclear localization signal in its N- terminus and is a chromatin associated cytokine [28] that can regulate gene expression by binding the p300-PCAF complex and activating genes in the NFkB and ...
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Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation.
... classical nuclear localization signal (NLS), and NLS point mutants are cytoplasmic and resistant to Vpx-mediated ...its nuclear localization; consequently, SAMHD1 K11A became sensitive ...
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Identification of a novel binding partner of phospholipase cβ1: translin-associated factor X.
... sitol 3-kinase and RhoGEF (see [8]). Another possibility is that one or more cytosolic proteins might promote the plasma member localization of PLCb1. With this idea in mind, we searched for alternate protein ...
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IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling.
... the nuclear localization of DVL in the canonical Wnt signaling ...that nuclear localization of DVL is necessary for the sequential activation of Wnt target genes [24], ...the nuclear ...
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Crystal structure of human importin-α1 (Rch1), revealing a potential autoinhibition mode involving homodimerization.
... minor nuclear localization signal (NLS) binding sites are completely buried in the homodimerization interface, an arrangement that restricts NLS ...
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The N-terminal 33 amino acid domain of Siva-1 is sufficient for nuclear localization
... this nuclear compartmentalization (2). However, no typical nuclear localization signal (NLS) could be found in the Siva-1 protein sequence, and no possible mechanism explaining its ...
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Myocardial ischemic preconditioning upregulated protein 1(Mipu1):zinc finger protein 667 –
... a nuclear factor with a variety of biological functions, such as participation in the process of myocardial ischemic preconditioning, protection of the myocardium from ischemic disease, and ...
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Distributed RSS-Based Localization in Wireless Sensor Networks Based on Second-Order Cone Programming
... RSS-based localization algorithm for WSNs was ...node localization based on RSS measurements was introduced in ...non-cooperative localization problem, where a single target node emits beacon frames ...
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Mutation inactivation of Nijmegen breakage syndrome gene (NBS1) in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
... second BRCT domain (amino acids β15–γβ4), and the Mre11- binding domain (amino acids 601–700, binding sites 665–69γ), as well as ATM phosphorylation sites [1γ,14]. Both the FHA and BRCT domains are essential for ...
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Components and regulation of nuclear transport processes
... sional structure of a protein masks its own transport signal as in the case of p105 [161], the precursor p50 subunit of NF-jB. Upon stimulation, p105 is phos- phorylated, the C-terminal part of the protein is ...
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Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p.
... ROS signal during growth (Pan et ...this signal is not generated even though respiration is up-regulated in puf3 D strains may explain why they do not have extended CLS ...
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Structural Basis of Importin-alpha-Mediated Nuclear Transport for Ku70 and Ku80
... monopartite nuclear localization sequences (NLSs), respec- tively, that allow them to be translocated to the nucleus independently of each other via the classical importin-α (Impα)/importin-β-mediated ...
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