Odontogenic tumor

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Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry

Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry

he adenomatoid odontogenic tumor (AOT) is a clinically benign lesion. Discussions about the AOT hamartomatous or neoplastic nature, and the probable odontogenic epithelial cell it originates from still exist. This research aimed to study and discuss the subject by the immunohistochemical detection of cytokeratins, laminin, collagen IV, PCNA and p53 in 8 tumor samples and 8 dental follicle samples containing reduced enamel epithelium. The results have shown that CK14 labelling indicated differentiation grades for secreting ameloblasts or ameloblasts in the post-secreting stage in the adenomatoid structure of AOT. Laminin, found on the luminal surface of adenomatoid structures, was compatible with the reduced enamel epithelium during the “protective stage of amelogenesis”. PCNA specifically labelled the spindled areas and peripheral cords of the AOT, indicating that these areas are responsible for tumor growth. After considerations about pathogenesis, the authors suggested that the nature of AOT is hamartomatous with histogenesis from the reduced enamel epithelium.
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Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs

Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs

In the present study, analyzing the immunohisto- chemical expression of integrins α2β1, α3β1, and α5β1 in ameloblastomas and AOTs (odontogenic tumors) and during the different stages of odontoge- nesis, important findings were obtained when evalu- ating the intensity of integrin staining, with the expression of these molecules tending to be stronger in ameloblastomas. The lack of detection of integrin α3β1 in tooth germs and its similar staining intensity in the odontogenic tumors studied suggest that this integrin might be used as a possible marker of neo- plastic transformation in odontogenic tissues. In addi- tion, blockade of integrins α2β1 and α5β1, which are more strongly expressed in ameloblastomas, may become an important strategy in the treatment or control of the local invasiveness of this tumor.
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Keratocystic odontogenic tumor : role of cone beam computed tomography and magnetic resonance imaging

Keratocystic odontogenic tumor : role of cone beam computed tomography and magnetic resonance imaging

Keratocystic odontogenic tumors (KCOTs) are known for unique and varied behavior, high recurrence rates, and distinctive histopathologic findings. Differential diagnosis and management of KCOTs may be challenging because other jaw lesions may present similar charac- teristics. Careful interpretation of cone beam computed tomograms and magnetic resonance images has great significance for precise assessment of KCOTs and their relationships to adjacent anatomic structures as well as for treatment planning. This case report describes

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Marsupialization and enucleation of keratocystic odontogenic tumor with the use of Carnoy's solution

Marsupialization and enucleation of keratocystic odontogenic tumor with the use of Carnoy's solution

Keratocistični odontogeni tumor lokalizovan u zadnjim partijama mandibule stvara dijagnostičku nedoumicu u po- gledu porekla i karaktera lezije. Na rendgen snimku u lume- nu KCOT nema zuba jer je nastao u periodu razvoja zubne klice. Međutim, često se u lumenu može naći neiznikli zub tako da KCOT u potpunosti liči na folikularnu cistu. Ovo se dešava naknadnom erupcijom impaktiranog zuba u lumen KCOT. Zbog moguće greške u dijagnostici i kasnijeg neade- kvatnog hirurškog tretmana biopsija većih cističnih lezija predela angulusa mandibule mora biti imperativ bez obzira da li se u njoj nalazi ili ne nalazi impaktirani zub. Osim toga, Sl. 3 – Koštana regeneracija godinu dana posle operacije
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RGO, Rev. Gaúch. Odontol.  vol.65 número4

RGO, Rev. Gaúch. Odontol. vol.65 número4

reports found in the literature, relative to its extensive size and expansive radiolucent aspect, with the presence of radiopaque regions within it, and with the aspect of possible rupture of the cortical bone, which could make a differential diagnosis with the calcifying epithelial odontogenic tumor and ameloblastic ibroma-odontoma 11 . Furthermore, the

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Braz. Dent. J.  vol.16 número1

Braz. Dent. J. vol.16 número1

Odontogenic tumors are remarkable among oral lesions because of their clinic and histologic heteroge- neity. This diversity reflects in the complex develop- ment of dental structures because odontogenic tumors derive from aberrations in odontogenesis. The amelo- blastoma deserves special attention, not only because of its particular biologic behavior, exhibiting great infiltrative potential, high recurrence rate and capacity to metastasize, but also due to the relatively high fre- quency that it is diagnosed among odontogenic tumors. The adenomatoid odontogenic tumor (AOT), on the other hand, in spite of sharing a common origin
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Rev. Bras. .  vol.73 número1 en a22v73n1

Rev. Bras. . vol.73 número1 en a22v73n1

Dentistry School of UFRN. After routine histology on the material, under light microscopy they observed fragments of the odontogenic lesion, characterized by the prolifera- tion of fusiform/globular cells, arranged as large islands and solid sheets, as well as numerous structures similar to ducts, lined by low cylindrical or cubic cells, of polarized nuclei (Figure 1b). Occasionally, some detached eosino- phylic amorphous material was, together with calcification areas (Figure 1c). We also noticed the presence of a cystic lesion coated by a stratified pavement epithelium, formed by few cell layers (Figure 1d), showing a continuity with the neoplastic foci aforementioned, and a connective fi- brous capsule. Histological diagnosis was of Adenomatoid Odontogenic tumor, associated with a dentigerous cyst.
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Braz. J. Oral Sci.  vol.12 número1

Braz. J. Oral Sci. vol.12 número1

Aim: To assess clinicopathological features of patients with keratocystic odontogenic tumor (KCOT) associated with nevoid basal cell carcinoma syndrome (NBCCS) in a single Brazilian institution. Methods: After histopathological analyses of KCOT related to NBCCS, the medical charts of 14 patients were assessed. These patients presented a total of 31 primary and 8 recurrent KCOT. Results: Out of 14 patients, 8 presented a single KCOT, 4 showed synchronous tumors, 1 had 3 metachronous lesions and another patient had 2 synchronous lesions at initial evaluation and then developed other 3 metachronous lesions. Besides the 31 primary KCOTs, 18 lesions were located in mandible and 13 in maxilla. Most tumors presented unilocular pattern and association with a tooth. Conclusions: KCOT is a frequent manifestation of NBCCS and can be its first sign, mainly in young patients. In contrast to a previously published series, most patients presented a single lesion.
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Braz. J. Oral Sci.  vol.12 número1

Braz. J. Oral Sci. vol.12 número1

, it was first considered to be a variant of OKC. However, with the World Health Organization (WHO) redefining OKC as a neoplasm and redesignating it as keratocystic odontogenic tumor (KCOT) in 2005, it became imperative that OOC had to be separated out from KCOT as a distinct entity. This distinction was germane as the pathogenesis and the progression and prognosis of these two seemingly similar odontogenic cysts is diverse. Equally bewildering of OOC is its resemblance to a dentigerous cyst when it occurs around the crown of an impacted tooth. This report presents a case of OOC in relation to an impacted mandibular third molar and discusses its possible pathogenesis.
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Braz. Dent. J.  vol.16 número3

Braz. Dent. J. vol.16 número3

Adenomatoid odontogenic tumor is a rare tumor that comprises only 0.1% of tumors and cysts of the jaw and 3% of all odontogenic tumors (1). It is an uncommon cause of jaw swelling. Common non-neoplastic causes of jaw swelling in this age group are apical cyst, dentigerous cyst, calcifying epithelial odontogenic cyst, odontogenic keratocyst, periapical granuloma and central giant cell granuloma.

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An Intricate Clinicopathologic Presentation of  Calcifying Odontogenic Cyst

An Intricate Clinicopathologic Presentation of Calcifying Odontogenic Cyst

True odontogenic cysts encompass an extensive part of jaw lesions wherein calcifying odontogenic cyst (COC) is an uncommon benign entity showing considerable amount of histopathological miscellany. 1 Calcifying odontogenic cyst was first recognized by Gorlin (thus named after him as ‘Gorlin cyst’), Pindborg, Praetorius- Clausen and Vickers in 1962 and later by Gold. Ever since its recognition, controversy and confusion have existed regarding the relationship between non-neoplastic, cystic lesions and solid tumor masses and is considered to occupy a position between a cyst and an odontogenic tumor, having some characteristics of both. Because of this diversity, a ‘dualistic’ concept has been proposed by
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Braz. Dent. J.  vol.22 número3

Braz. Dent. J. vol.22 número3

As syndecan-1 is typically expressed in epithelial cells, its expression can be important not only in malignant neoplasias, but also in benign tumors and lesions of the epithelial tissue, as are the majority of the odontogenic lesions. Recently, some authors reported that syndecan-1 expression in the extracellular matrix of ameloblastomas and diminished expression in tumor cells can determine a more aggressive local behavior of these lesions (7,15). This protein was also identified in the odontogenic epithelium and granular cells in a central granular cell odontogenic tumor, suggesting an important role in cell-cell adhesion and reciprocal interaction between these cell groups (16). Nevertheless, there are no studies evaluating the expression of syndecan-1 in odontogenic cystic lesions.
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Braz. Dent. J.  vol.25 número3

Braz. Dent. J. vol.25 número3

Ameloblastoma is a benign odontogenic tumor that presents various histologic growth patterns. The most common microscopic patterns are follicular and plexiform, followed by acanthomatous. This pattern is characterized by extensive metaplasia that is often associated with keratinization in the central portion of the epithelial islands. These islands tend to be arranged in an outer layer of columnar cells with nuclear palisading which resemble ameloblasts. The nuclei of these columnar cells are centrally polarized, oriented away from the peripheral basement membrane, and surround a central area in which neoplastic cells make a loose aspect resembling the stellate reticulum of the enamel organ (1,2).
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RGO, Rev. Gaúch. Odontol.  vol.65 número3

RGO, Rev. Gaúch. Odontol. vol.65 número3

The ameloblastic ibro-odontoma is a benign, mixed, asymptomatic and rare odontogenic tumor that can easily be confused radiographically and histologically with other diseases. Usually it affects a population between the irst and second decades of life, is more frequent in the mandible and shows predilection for males. This lesion, characterized by dental agenesis at the tumor site, has no predilection for anatomical region; however, an increase of intraoral volume may cause mild facial asymmetry. It shows slow but expansive growth, and is a well-deined radiolucent lesion, usually unilocular, with radiopacity inside. Normally surgical removal is conservative and the prognosis is favorable. This article reports a case of ameloblastic ibro-odontoma treated by surgical removal and follow-up of two years. The aim of this work was to study the ameloblastic ibro-odontoma in its entirety, seeking to inform clinicians about the best diagnostic and treatment methods for this type lesion.
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Calcifying Odontogenic Cyst with Complex Odontoma: Histological and Immunohistochemical Features

Calcifying Odontogenic Cyst with Complex Odontoma: Histological and Immunohistochemical Features

COC rarely can occur in conjunction with other odontogenic tumors such as ameloblastoma, ameloblastic fibroma, amelobastic fibro-odontoma and adenomatoid odontogenic tumor (16). Radioluscency accompanying odontoma or presence of soft tissue with odontoma during biopsy or operation, guided clinician toward four differential diagnosis including: cystic odontoma, COCaO, amelobelastic fibro-odontoma, odontoameloblastoma. Unlike other lesions, surgical resection with safe bony margin is recommended for odontoameloblastoma. However, conservative treatment (enucleation) is required for another lesion. COCaO is similar to the cystic COC, it has tooth like structures in the connective tissue of the cyst (11).
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J. Bras. Patol. Med. Lab.  vol.51 número6

J. Bras. Patol. Med. Lab. vol.51 número6

Although not pathognomonic, most SOTs are detected during routine radiographic examination as a radiolucent, unilocular, triangular-shaped image associated with the roots of adjacent teeth. The tumor may be misdiagnosed from the time when the lesion is referred to as a severe periodontal defect. Some rare cases exhibit a multilocular radiolucency, circumscription of the tumor with a cortical border or, in more aggressive cases, lack of deinition of tumor margins. In addition to advanced periodontal bone loss, Langerhans cell disease, lateral periodontal cyst, keratocystic odontogenic tumor, central odontogenic ibroma and other odontogenic tumors should be included in the radiographic differential diagnosis (2-6, 11-13) . Although computed
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Synchronous Occurrence Of Odontogenic Keratocyst And Giant Cell Granuloma –A Case Report

Synchronous Occurrence Of Odontogenic Keratocyst And Giant Cell Granuloma –A Case Report

Giant cell reaction has been reported in odontogenic tumors like ameloblastoma and odontogenic fibroma. The authors have interpreted these combinations as an odontogenic tumor with reactive giant cell response, although the initiating stimulus was

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J. Appl. Oral Sci.  vol.26

J. Appl. Oral Sci. vol.26

However, clear cells are not exclusive to CCOC. They may be observed in numerous neoplasias of the maxilla, such as the variant of clear cells seen in calcifying epithelial odontogenic tumor, odontogenic cysts, clear cell tumors of the salivary glands, and variations of carcinoma (e.g., acinar cell carcinoma, squamous cell carcinoma, and sebaceous tumors) 9 .

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Conservative Treatment Protocol for Keratocystic Odontogenic Tumour: a Follow-up Study of 3 Cases

Conservative Treatment Protocol for Keratocystic Odontogenic Tumour: a Follow-up Study of 3 Cases

The odontogenic keratocyst (OKC) is classiied as a developmental cyst derived from the enamel organ or from the dental lamina [1-3 ]. The deinition “odontogenic keratocyst” irst was proposed by Philipsen in 1956, when he separated seven jaw cysts from cholesteatomas occurring in other cranial areas. Because of his thought that these were odontogenic cysts and not inlammatory in origin, he coined the term odontogenic keratocyst [4]. Later it was noted that other odontogenic cysts, such as radicular cysts, follicular cysts, and lateral periodontal cysts, are morphologically similar to OKCs [5]. In contrast there were observations which showed that the odontogenic keratocyst behaved more as a neoplasm and not like a cystic lesion [6]. Finally, in the latest World Health Organization classiication, the former odontogenic keratocyst was added to the benign odontogenic tumours category. The new term is “keratocystic odontogenic tumor” (KCOT). In contrast to other odontogenic cysts, KCOTs have a high recurrence rate, reportedly ranging from 13% to 80% based on the performed treatment [7-12]. The malignant transformation of KCOTs has also been reported [13]. Treatment of KCOTs remains a controversial subject [14]. Most cases recur within the irst 5 years after treatment [15,16]. Many attempts have been made to reduce the high recurrence rate of KCOTs by improving the operative technique. Advocates of conservative treatment suggest that marsupialization yields the results comparable to those obtained with more extensive surgery [16].
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J. Appl. Oral Sci.  vol.19 número3

J. Appl. Oral Sci. vol.19 número3

as cystic are now classiied as cystic tumors, once the growth mechanism does not occur due to a difference in pressure, but rather for other reasons, such as epithelium activity proliferation. This is the case of the keratocystic odontogenic tumor (KOT), formerly known as odontogenic keratocyst. epithelial lining proliferation of KOT has a higher rate than non-odontogenic and radicular cysts, and is similar to the one found in ameloblastoma and the dental lamina 7 . Immunohistochemical staining

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