PH-responsive drug release
Dual-layered nanogel-coated hollow lipid/polypeptide conjugate assemblies for potential pH-triggered intracellular drug release.
... anticancer drug delivery, the polymeric vesicles supplemented with the pH-responsive outlayered gels as a delivery system of doxorubicin (DOX) were developed from self-assembly of the ...
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Synthesis and Characterization of pH Stimuli-Responsive Mesoporous Silica Nanoparticles
... in drug delivery systems (DDSs) as nanocarriers due their excellent biocompatibility, high surface areas, large pore volumes, high payload, uniform and tunable pore sizes, and versatile of surface ...the ...
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A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties
... IPECs are obtained by blending aqueous solutions of the corresponding polyelectrolytes. Their formation is favored by entropy gain afforded by the release of low- molecular-weight counter-ions upon complex ...
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Cell-Responsive Nanogels for Anticancer Drug Delivery
... the release of Dox into the cytosol and the nucleus (Figure ...the release behavior of Dox from the nanogels was studied in nonreducible and reducible environments, in PBS buffer, at pH ...possible ...
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Desenvolvimento experimental e simulação computacional de materiais poliméricos naturais para aplicações em Química Medicinal como “Drug Delivery Systems”
... with drug incorporation, these were filtered and placed in 500 ml distilled water or saline solution, which had a pH for simulating human conditions, obtained using a hidrogenophosphate ...
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Mat. Res. vol.17 número3
... paclitaxel release from PLDLA microspheres was characteristic of systems containing carriers of different diameters, with the smaller diameter microspheres releasing the drug rapidly while larger ...
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Low Generation Degradable Dendrimer Nanoclusters for Delivery of Anti-cancer Drug
... corresponding drug free systems, suggesting that the cytotoxic effect was only due to the drug loaded within the ...DOX release ability from the ...
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Development of a poly(L-Lactic acid) based drug release system
... the drug, which could indicate a greater loading, but also a faster ...highest drug loading comparing to the H+ and ...the drug, with higher ratios yielding greater ...a drug in a zeolitic ...
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Reliability of a Novel Model for Drug Release from 2D HPMC-Matrices
... of drug release from 2D-HPMC matrices is ...initial drug loading are ...of drug release parameters under available experimental ...of drug release in two cases (with and ...
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Braz. J. Pharm. Sci. vol.48 número4
... a drug in a speciic application requires the maintenance of appropriate drug blood level concentration during a prolonged period of ...Controlled release delivery is available for many routes of ...
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Braz. J. Pharm. Sci. vol.49 número3
... that drug levels should be assessed at least eight different sites: at four of the sites levels are measured during uptake ...the drug from the remaining sites, levels are assessed during clearance ...of ...
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Braz. J. Pharm. Sci. vol.53 número1
... Colon‑targeted drug delivery systems have been increasing interest for treating colonic diseases such as Crohn’s disease, irritable bowel syndrome, and ulcerative colitis (Chourasia, Jain, 2004; Jain, Jain, 2008; ...
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Coaxial Electrospray of Curcumin-Loaded Microparticles for Sustained Drug Release.
... the drug LR is mainly deter- mined by the weight ratio of curcumin in the total ...producing drug-loaded MPs with satisfactory morphology, narrow size distribution, high EE and LR of drugs, in comparison ...
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Braz. J. Pharm. Sci. vol.50 número1
... of drug absorption, (c) Selective targeting of drug(s) towards speciic absorption window in GIT, (d) Protection of drug(s) from the hostile environment in gut, (e) Control of delivery proiles, (f) ...
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Formulation and Characterization of Transdermal Patches of Losartan
... anti-hypertensive drug losartan as transdermal patch using different bioadhesive polymers such as ethyl cellulose, cellulose acetate, and polyvinyl pyrrolidon,hydroxyl propylemethylcellulose with plasticizers ...
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Braz. J. Pharm. Sci. vol.47 número3
... sustained release loating ...vitro release from the formulation was studied as per the USP XXIII dissolution ...normal release effect followed by sustained release for 12 h which indicates ...
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Braz. J. Pharm. Sci. vol.48 número2
... vitro release in 8 h and 67% permeation of drug through porcine buccal mucosa and followed ickian release mechanism with zero order ...the drug and ...
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Molecularly imprinted polymers for controlling drug release. Part 1: synthesis and characterization.
... MOLECULARLY IMPRINTED POLYMERS FOR CONTROLLING DRUG RELEASE. PART 1: SYNTHESIS AND CHARACTERIZATION. Molecularly imprinted polymers (MIPs) consist of synthetic macromolecular matrix, obtained through ...
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Rev. bras. farmacogn. vol.23 número1
... content release when the test was performed in a hydrochloric acid buffer (pH ...maximal release rate at 15 min (giving a polyphenol content of ...maximal release was reached at 20 min (giving ...
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EFFECT OF KONDAGOGU ON THE RELEASE BEHAVIOUR OF AMBROXOL HYDROCHLORIDE MATRIX TABLETS
... was maintained at 100 rpm. 900 ml 0.1N HCl and the phosphate buffer pH 6.8 was used as dissolution medium for the first 2 hours and from 3 to 12 hours respectively, which was maintained at 37± 0.2°C. Aliquots of 5 ...
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