Platelet-derived growth factor signaling
Prostate field cancerization: deregulated expression of macrophage inhibitory cytokine 1 (MIC-1) and platelet derived growth factor A (PDGF-A) in tumor adjacent tissue.
... PDGFR signaling pathway is strongly implicated in the development and progression of prostate cancer [21,22], its capacity as inde- pendent prognostic biomarker in prostate cancer has not been thoroughly ...
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Blocking TGF-β Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRβ+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats.
... transforming growth factor beta (TGFβ) (CD105-endoglin: !) and (d) phosphorylated Smad2/3 (!) around fibrotic areas ...endothelial growth factor (VEGF) (!) was found in several atrophic ...
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Rev. Col. Bras. Cir. vol.36 número4
... the platelet derived growth factor/platelet derived growth factor receptor- signaling pathway in the tumor progression and angiogenesis of gastric ...
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A Switch in the Dynamics of Intra-Platelet VEGF-A from Cancer to the Later Phase of Liver Regeneration after Partial Hepatectomy in Humans.
... Hepatocyte growth factor (HGF) and epidermal growth factors (EGF) are the major mitogens; the breach in the signaling pathways associated with these factors would likely abolish the pro- cess ...
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Análise da expressão gênica diferencial das glândulas de veneno de Bothrops jararaca...
... protein signaling pathway; P:tyrosine phosphorylation of STAT protein; P:signal transduction; P:erythrocyte differentiation; P:hormone- mediated signaling pathway; F:insulin receptor substrate binding; ...
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Arq. NeuroPsiquiatr. vol.71 número9B X anp 71 09b 677
... as proangiogenic molecules (vascular endothelial growth factor [VEGF], urokinase plasminogen activator [uPA], and tissue plasminogen activator [tPA]) have also been evalua- ted. In the majority of studies, ...
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Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling.
... standards of a 5 Angio mix peptides (Michrom Bioresources, Inc., Auburn, CA) were run to ascertain column performance, and observe any potential carryover that might have occurred. The LCQ was run in a top five ...
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Epithelial mesenchymal transition is required for acquisition of anoikis resistance and metastatic potential in adenoid cystic carcinoma.
... that growth factor signaling pathways mediating the EMT process might also contribute to anoikis resistance ...EGFR/PI3K/Akt signaling pathway acts as the common regulator for EMT-like ...
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Estrous cycle dependent fluctuations of regulatory neuropeptides in the lower urinary tract of female rats upon colon-bladder cross-sensitization.
... Steroid hormones show the capacity to modulate neurogenic inflammation and nociceptive signaling due to a widespread expression of estrogen receptors (ER) in the pelvic organs and associated neural pathways. Both ...
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Rev. Soc. Bras. Med. Trop. vol.48 número4
... Human platelet antigen polymorphisms are associated with the rapid development of fi brosis in HCV-monoinfected ...human platelet antigens-1, -3, or -5 ...human platelet antigen polymorphisms and fi ...
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Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways.
... dependent signaling being involved only in anti-apoptotic but not in the proliferation-stimulating actions of IGF1 ...WNT signaling, long-term GSKγi has been associated with reduced, rather than increased, ...
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Arq Bras Endocrinol Metab vol.51 número4
... The multichaperone heat shock protein (Hsp) 90 complex mediates the maturation and stability of a variety of proteins, many of which are crucial in oncogenesis, including epidermal growth factor receptor ...
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Decrease of urinary nerve growth factor but not brain-derived neurotrophic factor in patients with interstitial cystitis/bladder pain syndrome treated with hyaluronic acid.
... function [17,18]. Elevated levels of circulating NGF might also increase the excitability or susceptibility of sensory receptors in suburothelial nerve fibers such as purinergic receptors P2X3 and transient receptors ...
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Rev. Hosp. Clin. vol.57 número5
... ZHANG C, HSUEH W, CAPLAN MS, KELLY A - Platelet- activating factor-induced shock and intestinal necrosis in the rat: role of endogenous platelet-activating factor and effect of saline in[r] ...
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Clinics vol.66 número5
... protein-induced growth arrest and apoptosis in tumor B cell lines, 30 and the overexpression of Smad7 in the adventitia of the carotid arteries significantly attenuated a-smooth muscle actin expression in the ...
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Linfangiogênese e seu papel no diagnóstico diferencial entre tumores mucinosos primários...
... Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. Krishnan J, Kirkin V, Steffen A, Hegen M, Weih D, [r] ...
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MODULATION of LEISHMANIA (L) AMAZONENSIS GROWTH in CULTURED MOUSE MACROPHAGES BY PROSTAGLANDINS and PLATELET-ACTIVATING-FACTOR
... Macrophages were treated with 10 -5 M of the antagonists BN-52021 or WEB-2086, 1 h before addition of PAF at 10 -6 M concentration to the culture medium and the phagocytic index was dete[r] ...
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Arq. Bras. Oftalmol. vol.71 número6 suppl.
... As tear film hypertonicity is often associated with dry eye, it is conceivable that this condition is a consequence of dys- functional RVI responses. Under this condition, hypertoni- city-induced cell shrinkage results ...
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Genome-wide identification of Bcl11b gene targets reveals role in brain-derived neurotrophic factor signaling.
... nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4) (Figure 5) of which BDNF is the most widely ...intracellular ...
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Formal modeling and analysis of ER-α associated Biological Regulatory Network in breast cancer
... IGF signaling and activate its downstream pathways by increasing the expression of both IRS-1 and IGF-1R in BC cells (Fagan & Yee, 2008; Lee et ...ER-α signaling pathways are actively involved in the ...
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