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RNA splicing

Strategies for identifying RNA splicing regulatory motifs and predicting alternative splicing events.

Strategies for identifying RNA splicing regulatory motifs and predicting alternative splicing events.

... Alternative Splicing The principal computational approach to identifying AS genes, and to infer individual alternative exon events or complete alternative isoform structures, relies on the comparison of available ...

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Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells.

Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells.

... oncogenic RNA splicing to devitalize to human cancer cells but not some human normal cells we tested, are 1- to 3-order higher than peripheral blood plasma levels achieved by doses of amiloride administered ...

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Temporal and tissue specific regulation of RP-associated splicing factor genes PRPF3, PRPF31 and PRPC8--implications in the pathogenesis of RP.

Temporal and tissue specific regulation of RP-associated splicing factor genes PRPF3, PRPF31 and PRPC8--implications in the pathogenesis of RP.

... no splicing defect was observed when the endogenous Hprp3p was replaced by the RP18 mutant protein via a helper-dependent adenoviral vector that simultaneously knocks down the endogenous Hprp3p and expresses a ...

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Small-molecule inhibition of HIV pre-mRNA splicing as a novel antiretroviral therapy to overcome drug resistance.

Small-molecule inhibition of HIV pre-mRNA splicing as a novel antiretroviral therapy to overcome drug resistance.

... both splicing activity and subcellular trafficking of SR proteins [38], treatment of cells with IDC16 may modulate these two processes and act synergistically to modify HIV-1 RNA splicing and/or ...

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Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

... mRNA splicing are crucial not only for the precise transcription- al regulation of any given gene but also for the functional stability of the transcriptome [33, ...aberrant splicing has been described as a ...

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BRR2a Affects Flowering Time via FLC Splicing.

BRR2a Affects Flowering Time via FLC Splicing.

... linking RNA splicing to flowering time are not well ...FLC splicing and greatly reduced FLC transcript ...efficient splicing of a subset of introns characterized by a combination of factors ...

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Arq Bras Endocrinol Metab  vol.53 número6

Arq Bras Endocrinol Metab vol.53 número6

... RNA splicing is an essential, precisely regulated process that occurs after gene transcription and before mRNA translation, in which introns may be removed and exons, ...in splicing patterns is a ...

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Intronic Alus influence alternative splicing.

Intronic Alus influence alternative splicing.

... total RNA was extracted, and splicing products were separated on a 2% agarose gel after RT-PCR ...1, splicing products of wt RABL5 minigene. Lanes 2–13, splicing products of the indicated ...

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Proteasome-mediated proteolysis of SRSF5 splicing factor intriguingly co-occurs with SRSF5 mRNA upregulation during late erythroid differentiation.

Proteasome-mediated proteolysis of SRSF5 splicing factor intriguingly co-occurs with SRSF5 mRNA upregulation during late erythroid differentiation.

... SR splicing factors (SRSFs, [1]) are highly conserved family of regulators of pre-mRNA ...spliceosomal splicing factors, including SR proteins ([3,4], and references ...an RNA-recognition motif (RRM) ...

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UNIVERSIDADE FEDERAL DO CEARÁ CENTRO DE CIÊNCIAS AGRÁRIAS DEPARTAMENTO DE ENGENHARIA DE PESCA AVALIAÇÃO DOS MÉTODOS DE EXTRAÇÃO DE RNA TOTAL NAS ALGAS

UNIVERSIDADE FEDERAL DO CEARÁ CENTRO DE CIÊNCIAS AGRÁRIAS DEPARTAMENTO DE ENGENHARIA DE PESCA AVALIAÇÃO DOS MÉTODOS DE EXTRAÇÃO DE RNA TOTAL NAS ALGAS

... O Concert Plant RNA Reagent foi o método mais eficaz para a extração de RNA total das macroalgas marinhas vermelhas Hypnea musciformis.. e Hypnea cervicornis, fornecendo RNA com qual[r] ...

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Protein-RNA linkage and posttranslational modifications of feline calicivirus and murine norovirus VPg proteins

Protein-RNA linkage and posttranslational modifications of feline calicivirus and murine norovirus VPg proteins

... the RNA, was trypsin digested and the RNA was subsequently hydrolyzed in 10% trifluoroacetic acid for 48 h at room ...total RNA, measured by an absorbance-based quantitation (NanoDrop), was used per ...

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Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation.

Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation.

... the splicing reaction [1–3]. Although pre-mRNA splicing is an important part of regulated gene expression, little is known about the assembly and activation of spliceosomes in ...

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An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.

An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.

... epithelial-specific splicing of a number of genes, some of which have well documented and essential roles in EMT ...mesenchymal splicing program to an epithelial state and allow us to examine the role of ...

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ASPECTOS EVOLUTIVOS DO SPLICING ALTERNATIVO

ASPECTOS EVOLUTIVOS DO SPLICING ALTERNATIVO

... por splicing alternativo e, posteriormente, repetiu-se a análise com outros organismos (camundongo, drosófila e o nematóide Caenorhabditis ...de splicing alternativo em genes duplicados tende a ser mais ...

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P68 RNA helicase (DDX5) alters activity of cis- and trans-acting factors of the alternative splicing of H-Ras.

P68 RNA helicase (DDX5) alters activity of cis- and trans-acting factors of the alternative splicing of H-Ras.

... four splicing factors by means of RNAi- mediated depletion assays to determine how (1) endogenous p19 abundance is affected and (2) the expression of other genes is ...four splicing factors were obtained ...

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Study of the ground-state geometry of silicon clusters through artificial neural networks.

Study of the ground-state geometry of silicon clusters through artificial neural networks.

... a RNA identifique quais camadas tendem a se ligar mais fortemente entre ...a RNA prevê como energeticamente favoráveis, podemos evitar que o algoritmo de busca desperdice o tempo de cálculo com estru- turas ...

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A new strategy for RNA isolation from eukaryotic cells using arginine affinity chromatography

A new strategy for RNA isolation from eukaryotic cells using arginine affinity chromatography

... for RNA isolation from a biological source, because of its unique char- acteristic of using a biospecific ligand to purify biomolecules, on the basis of their biological function or individual chemi- cal ...of ...

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SINE RNA induces severe developmental defects in Arabidopsis thaliana and interacts with HYL1 (DRB1), a key member of the DCL1 complex.

SINE RNA induces severe developmental defects in Arabidopsis thaliana and interacts with HYL1 (DRB1), a key member of the DCL1 complex.

... SB1 RNA (indicated by asterisks on Figure ...to RNA conformation and, although sensitivity does not always imply hydrogen bonding of the bases in a canonical double stranded helix, it does require a ...

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Caracterização funcional das isoformas de splicing do gene ADAM23

Caracterização funcional das isoformas de splicing do gene ADAM23

... three splicing isoforms, α, β and γ, that code for proteins with different C-terminal ...three splicing isoforms of ADAM23 gene in five normal tissues (breast, colon, brain, prostate and pancreas) and in ...

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