secretory pathway.
A dynamic study of protein secretion and aggregation in the secretory pathway.
... A significant advantage of the Halo domain is its ability to covalently bind ligands with tailored features. In this study, we exploited this property to visualise and quantify the traffic, condensation and degradation ...
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The regulated secretory pathway in CD4(+) T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapse.
... contact-dependent secretory pathway may con- tribute to directing retroviral proteins to intercellular ...the secretory apparatus proximal to the VS, as demonstrated for HTLV-1 and implied by studies ...
20
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.
... Intriguingly, atf-6 deficiency only affected about six i-UPR genes, none of which appeared to be directly involved in ER protein folding, secretion, or ERAD (Table S2). The negligible role of worm atf-6 in regulating ...
14
Exploring the Fasciola hepatica tegument proteome
... expanded secretory vesicles, but also the observation of sperm and a single egg in the S2P fraction, prior to UTCS ...and secretory pathway proteins ...
13
The interaction between the first transmembrane domain and the thumb of ASIC1a is critical for its N-glycosylation and trafficking.
... These results suggest that reducing the culture temperature facilitates the folding and subsequent maturation of ASIC1a through the secretory pathway, and further predicts an increase in[r] ...
10
Drosophila KDEL receptor function in the embryonic salivary gland and epidermis.
... core secretory machinery as well as with null mutations in the CrebA transcription factor gene, which is known to coordinately upregulate secretory machinery genes in specialized secretory cells – ...
11
Lactation defect with impaired secretory activation in AEBP1-null mice.
... likely due to AEBP1 disruption. We have previously shown that AEBP1 stimulates cell growth and survival and inhibits apoptosis through positive regulation of MAPK [11] and negative regulation of PTEN [14,15]. AEBP1 was ...
9
Extensive Admixture and Selective Pressure Across the Sahel Belt
... Three other regions show signals of positive selection in almost all populations across Sahel, in the iHS analysis (fig. 2). One is located on chromosome 12 around the SPATS2 gene (supplementary figs. S20 and S21, ...
12
Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI.
... platelet secretory response without causing any of the other major changes that usually accompany platelet activation and that were observed at higher collagen ...selective secretory response of platelets ...
10
Secretory spaces in species of the clade Dipterygeae (Leguminosae, Papilionoideae)
... in secretory canals and cavities, with medicinal ...histochemistry. Secretory spaces, i.e. secretory cavities and canals, exhibited a wide lumen and a single layer of ...species. Secretory ...
8
Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility.
... p-value for the androgen-estrogen conversion sub-pathway would still be as low as 0.014. To further ensure that the observed associations could not be due to the employment of 319 paraffin- embedded tissue samples ...
8
J. Bras. Nefrol. vol.35 número4 en v35n4a13
... Transforming growth factor-β (TGF-β), monocyte chemotactic protein-1 (MCP-1), intercellular adhesion molecules (ICAM) and HO-1 have been implicated in cisplatin nephrotoxicity. Significant up-regulation of TNF-α, TGF-β, ...
9
Implementation of fuzzy system using different voltages of OTA for JNK pathway leading to cell survival/ death
... In this paper a well defined method for the design of JNK pathway for epidermal growth factor/ insulin using fuzzy system using operational transconductance amplifier was discussed. Fuzzy system includes ...
9
Biological characterization of compounds from Rhinella schneideri poison that act on the complement system
... in the literature. Spider (Loxosceles), snake (Elapidae, Crotalidae and Viperidae), honeybee, wasp and scorpion venoms have demonstrated the ability to activate the CS [30–35]. This activation can be initiated by ...
12
Indoor Navigation to Support the Blind Person Using True Pathway within the Map
... the pathway with features detected by the system, where the ...the pathway by the EKF, while the blue line is the actual pathway that the user take it, finally the red line is the true pathway ...
8
Ancient origins: complement in invertebrates
... classical pathway is initiated by antibody-antigen complexes via complement component C1, the lectin-mediated pathway is activated by collagenous lectins (collectins or ficolins) utilizing mannose binding ...
10
JWA deficiency suppresses dimethylbenz[a]anthracene-phorbol ester induced skin papillomas via inactivation of MAPK pathway in mice.
... MEK/ERK pathway [19,30], since this pathway is identified to regulate fundamental processes in normal and malignant cells, including proliferation and cell survival ...
10
Study of global transcriptional changes of N-GlcNAc2 proteins-producing T24 bladder carcinoma cells under glucose deprivation.
... Image analysis and base calling were performed using Off-Line Basecaller Software 1.6 (Illumina). Reads were aligned using ELAND v2 of CASAVA Software 1.7 with the sequence data sets. Transcript coverage for every gene ...
13
Pathway-based screening strategy for multitarget inhibitors of diverse proteins in metabolic pathways.
... a pathway-based screening strategy that simultaneously screens proteins in a metabolic pathway for discovering multitarget ...developed pathway site-moiety maps that present the conserved binding ...
14
Analysis of the effect of the over-expression of recptor activator of Nf-kB (RANK) in estrogen receptor-positive breast cancer cells over tumour behaviour in vivo
... RANK-RANKL pathway has been implicated in several contexts of BC disease, from early tumorigenesis to progression and ...RANKL pathway in the context of BM has been addressed for ...
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