Fault Tree analysis (FTA) is a powerful rational and deductive technique for analyzing the system operation, safetyand elucidating the causal relations leading to a given unwanted event. It is a systematic approach to enumerate malfunctioning of process ingredients and exam- ined symptoms diagrammatically. Thus, it helps to explicate the mechanism of an undesired happening due to a fault or a combination of faults and failures [6, 7]. The contemporary work is a case study of a leading paper and board mill in Pakistan. The specific objective of this case study is to sort out operational problems related to steam consumption and condensate recovery using fault tree analysis approach.
southern region which had the highest commercialization rate in 2017, with 165 thousand tons of active ingredient reaching 30.61% of the national market. This reality was demonstrated by Pignati et al. (2017), being MT (Mato grosso), the state with the largest soybean and corn plantation in the country, as well as the one that consumed the most pesticides in 2015, therefore, having essential weight in the consumption of these substances. Between 2015 and 2016, there is a decrease in the marketing of these substances in the southern (0.31%) and southeast (6.31%) regions, a similar reality identified in a study on the profile of pesticide use in Southwestern Brazil. Paraná performed by Gaboardi et al.(2019), in which they presented official data of growth in previous years and fall in 2016, suggesting as a hypothesis of this smuggling due to proximity to the border, other hypotheses were listed; however, they were not made, specific studies to prove them such as: reduction in agricultural production, reduction by improvement of management technique or some kind of inconsistency in the data.
ABSTRACT – Background – One of the most feared complications with the use of cyanoacrylate for treatment of gastric varices is the occurrence of potentially life-threatening systemic embolism. Thus, endoscopists are turning towards new techniques, including endoscopic coiling, as a potentially safer and more effective treatment option. However, no studies have been performed comparing the two techniques. Objective – This study aims to compare the safetyand efficacy of endoscopic ultrasound guided coil and cyanoacrylate injection versus the conventional technique of injection of cyanoacrylate alone. Design – A pilot randomized controlled trial. Methods – Patients randomized into group I were treated with coil and cyanoac- rylate, and those in group II with cyanoacrylate alone. Flow within the varix was evaluated immediately after the treatment session and one month following initial treatment. If thrombosis was confirmed, additional follow-up was performed 4 and 10 months following initial treatment. All patients underwent a thoracic computerized tomography scan after the procedure. Results – A total of 32 patients, 16 in each group, were followed for an average of 9.9 months (range 1-26 months). Immediately after the procedure, 6 (37.5%) group-I patients and 8 (50%) group-II patients presented total flow reduction in the treated vessel (P=0.476). After 30 days, 11 (73.3%) group-I patients and 12 (75%) group-II patients were found to have varix thrombosis. In both groups, the majority of patients required only one single session for varix obliteration (73.3% in group I versus 80% in group II). Asymptomatic pulmonary embolism occurred in 4 (25%) group-I patients and 8 (50%) group-II patients (P=0.144). No significant difference between the groups was observed. Conclusion – There is no statistical difference between endoscopic ultrasound guided coils plus cyanoacrylate versus conventional cyanoacrylate technique in relation to the incidence of embolism. However, a greater tendency towards embolism was observed in the group treated using the conventional technique. Both techniques have similar efficacy in the obliteration of varices. Given the small sample size of our pilot data, our results are insufficient to prove the clinical benefit of the combined technique, and do not yet justify its use, especially in light of higher cost. Further studies with larger sample size are warranted.
Eliminate unnecessary materials, tools, parts, equipments. Sorting identifies necessary information for the realization of tasks. Sorting eliminates the waste raw materials, nonconforming stock, and damaged tools. Keep only necessary items and eliminate what is not required. It improves the efficiency of searching and collecting items, reduces the running time of operation. Sort is the concept helps the company to keep everything they need and throw non-use items away Based on Sort concept, a company collects all items that it has now and determines whether or not it will be used, distinguishing the items into two different categories: used and non-used. In Bajaj Steel Industry, they have several places that the owner uses for setting all welding. Grinding and painting. Yet, Industry never has a place for setting specific shop for painting and raw material is placed anywhere due to this product should be damaged. By sort step, Industry looked at each inventory place and confirmed what the company needed, then what they did not need, and what was broken.
A specific classification for the reporting of adverse reac- tions associated with biologicals has been developed . When side effects do not show a temporal coincidence with the use of medicines, it is normal to find a reduced number of notifications of suspected adverse reactions. In such a case, the role of pharmacists is essential and relevant, as society depends on them to ensure the traceability of biologicals . The traceability of biologicals can be ensured through an integrated individual record of prescriptions or through the enrolment of patients in an observatory for monitoring. The literature also proposes establishing a serologic library with registries of the development of antibodies associated with the administration of drugs of different brands .
The CAMS (Cannabinoids in MS) study included 667 patients from 33 centres in the UK, who were randomized to either synthetic Δ-9-THC (Marinol ®), whole-plant extract (Cannador ®: containing 2,5mg of Δ-9-THC equivalent and 1,25mg of CBD) or placebo capsules for 15 weeks, as an add-on therapy. The primary endpoint of this study was to evaluate the change in MS related spasticity from baseline to week 13, using the Ashworth score, which is dependent on the assessor’s estimation and experience. (15) 211 patients were allocated to the cannabis extract arm (Cannador ®), 206 to the Marinol ® arm and 213 received placebo, bringing up a total of 630 patients in the intention-to-treat analysis. During week 14, patients were instructed to reduce dosage so as to be off trial medication by week 15. Interestingly, the results from the study show no improvement in spasticity, according to the Ashworth score (p=0.40); however, patients reported a preference for the active treatment, as it felt better in managing some of their symptoms, namely pain (p=0.002), sleep quality (p=0.025), spasms (p=0.038) and spasticity (p=0.010), while others suffered no change (irritability, tremor, depression or energy). (15) The most reported side effects among the active groups were expected and included dizziness/light- headedness, dry mouth, diarrhoea as well as an increase in appetite.
Biosimilar medicinal products have become a reality in recent years. Despite an established legal pathway for biosimilars in the European Union since 2005 and increasing regulatory guidance on data requirements for their development and approval, many clinicians are still reluctant to consider biosimilars as a treatment option for their patients. Moreover, the approval of biosimilars has prompted the discussion of whether these products can be safely switched with the innovator biopharmaceuticals without a negative impact on the efficacy of the treatment or an increased risk of immunogenicity. This review gives an overview of the available data related to the switch between an originator product and a biosimilar. A search was conducted for pre- and post-approval clinical studies involving patients that were switched between innovator drugs and EMA approved biosimilars. Currently, there is limited clinical data that specifically investigates the effects of switching. Nevertheless, the data analyzed from clinical studies reporting on switching between originator products and their respective biosimilars indicates that switching has no impact on the efficacy, safetyand immunogenicity of treatment in patients.
Quality of fruit and vegetables is defined at harvest, and postharvest technologies only ensure that the rate at which products’ quality decline is minimized. Fruit growers are faced with the problem of producing enough quantities to be profitable but also to produce with high intrinsic quality. For consumers, flavor andsafety are the most important characteristics of quality. The main factors that affect flavor quality are the genotype (cultivars/rootstocks), maturity at harvest, environment and cultural practices and the cross effect between them. Pest and diseases control with pesticides, the use of growth regulators to improve quality and consumer acceptance also play an important role in cultural practices and are firmly related to safety. Some examples of preharvest factors influencing quality andsafety of fruits will be discussed, given that postharvest quality is based both on better flavor and safer products, as well as in long shelf life and high acceptability. In the future, producers will have to identify all factors that influence composition and quality and to use environmental friendly technologies that are able to increase postharvest quality.
The papers selected by our Scientific Committee Board is a testament to the calibre of the research that is on-going around the world. Unfortunately, we could not accept all the papers submitted for oral sessions although we had a strong poster session to tackle interesting emerging research. Moreover, two Invited Lectures abo ut “PANIC IN FIRE EMERGENCIES: MYTH OR REALITY?” and “TRAVELLING FIRES FOR STRUCTURAL DESIGN” were given by Prof. Dr. Daniel Nilsson, Lund University (Sweden) and Prof. Dr. Guillermo Rein, Imperial College (UK) respectively.
As remarked in , observable hyperproperties generalize the notion of observable properties . It can be shown that there exists a non-empty observable property that is not a liveness property (e.g., the set of all traces that starts with σ ). In contrast, Theorem 3.6 states that every non-empty observable hyperproperty is also a liveness hyperproperty. Intuitively, this follows because the hyperproperty ex- tension relation ≤ allows the right-hand side to contain traces that does not appear in the left-hand side. Therefore, for any T ∈ Obs, there exists T ′ ∈ Prop that contains T and an evidence of the observable
Consumer behavior is stated as the behavior that consumer display in searching for, purchasing, using, evaluating, and disposing of products, services and ideas that they expect will satisfy their needs. The study of consumer behavior is concerned not only with what consumers buy, but also with why they buy it, when and how they buy it, and how often they buy it. )t is concerned with learning the specific meanings that products hold for consumers. Consumer research takes places at every phase of consumption process, before the purchase, during the purchase and after the purchase. According to Philip Kotler defined consumer behavior as all psychological, social and physical behavior of potential customers as they become aware of evaluate, purchase, consume and tell other about products and services . The scope of consumer behavior includes not only the actual buyer and his act of buying but also various roles played by different individuals and the influence they exert on the final purchase decision .)ndividual consumer behavior is influenced by economic, social, cultural, psychological, and personal factors. A decision is the selection of an action from two or more alternative choices. Consumer decision to purchase the goods from the available alternative choice is known as consumer purchase decision . The various options of the consumer may be classified into five main types of decisions. They are what to buy, how much to buy, where to buy, when to buy, how to buy. The participants in the buying decisions may be classified as the initiator, influencer, decider, buyer and users. The marketing people should initiate the participants in the purchase decision to make the purchases of the product at different marketing strategies. There are number of reasons why the study of consumer behavior developed as separate discipline. Marketers had long noted that consumer did not always act or react, as marketing theory would suggest.
Poultry raising is one of the most dynamic sectors of domestic meat production, which, during the last years, succeeded in shrinking the gap recorded in the period – as compared to Community competition. With over . million small farms, the great majority being subsistence farms, representing almost % of the total number of farms recorded at the EU level, the local avian sector has the greatest number of units with under , broilers and only . % of the total number of large farms. The great development recorded by the sector, which in succeeded in balancing poultry meat foreign trade is due to some modern units that implemented an integrated production system with fodder factories, poultry raising farms, processing units and distribution systems Van, . The technical performances recorded by the sector in placed the local poultry sector on the fourth place in the world and on the third place in Europe AM PNDR, . Almost % of the local poultry market is owned by companies such as Transavia, Ave Grup, Avicola Buzău or Avicola Bacău. The increase in end product added value for these companies is achieved not only by slaughter, packaging and conservation processes of the poultry raised in own farms, but also by means of secondary processing and some processed meat products or of ready to eat/ready to meal products. The most important poultry companies developed own brands, differentiated for poultry meat production and highly processed products.
Since localization is the initial step in any iris recognition technique, it is important to know the time complexity for localizing the iris as fast as possible. The most important metrics of localization algorithm is accuracy and speed. The implementation of new iris localization technique is done using MatLab R2012a on core2 Duo Intel with 2.00 GHz speed. The Integro-differential operator is very sensitive to noise and takes more time to localize the iris. It does not consider the high frequency variation. It is very difficult to improve the recognition accuracy with Hough transform. Using our approach the above said problems and the problems like eyelash obstruction, eyelid occlusion, reflection and blurring has been solved easily. The iris localization process is faster and required time for iris localization is less. The iris localization rate achieved is 87.50% for right iris and 88.46% for left iris images respectively. Experimental result shows that the proposed method achieves better performance in both accuracy and speed in iris localization.
The questionnaires were distributed to the Surgeons, Nurses, Anesthesiologists, Radiographers and Auxiliaries by the head nurse and head Anesthesiologist or the researcher and had to be completed within 2 months. All questionnaires were collected in a (secured) box on the ward. Every week, a reminder was sent to ward staff. Respondents were informed that participation was voluntary. Questionnaires were treated anonymously, and that the decision to return a completed questionnaire was deemed their informed consent. The study was approved by the Medical Ethics Committee of Algarve’s Hospital Center (Centro Hospitalar do Algarve – CHA).
these surgeries. The DMEK graft was prepared in the operating room under sterile conditions immediately preoperatively. The donor button was placed on a sterile flat surface. The rim then was stabilized with toothed forceps, and the periphery was scored using a Sinskey hook to break through the DM for 360° without compro- mising the stromal fibers. To allow better visualization, we used a few drops of trypan blue 0.05% to stain edges of the DM. The rim then was submerged under balanced salt solution (BSS) in a trephine system block, and the edge of the DM was grasped with nontoothed forceps to strip it away slowly from the stroma. Approximately 30% to 40% of the DM was stripped before trephinating the DM partially through the stroma with an 8.5- to 9.0-mm donor trephine. The donor cornea then was submerged again to complete the DM stripping across the trephina- ted area, forming a scroll with the endothelium outside. The DM roll then was stained with trypan blue 0.05% for 40 to 60 s to improve visualization while inserting and positioning it in the recipient cornea.
Concretely, the use of pesticides in olive orchards provides an unquestionable benefit for crop protection. Nevertheless, if these pesticides persist up to the harvest stage trace amounts of those contaminants could be found in olive oil, since it is obtained from the olives exclusively by mechanical and/or physical means, without any subsequent treatment (García-Reyes et al., 2007). Therefore, the development of robust and reliable analytical methodologies that enable the trace analysis of pesticide residues in this complex food matrix is highly warranted. However, this task could be very challenging due to the presence of several interferents in olive oil matrix that could interfere in the chromatographic analysis, hampering an accurate trace analysis of the pesticide residues (Gilbert-López et al., 2009). Thus, the isolation/pre-concentration of these analytes in high complex matrices is mandatory being a crucial step for the attainment of the desired low MRLs enforced by the legislation.
Fig. 31: Longitudinal scan identify transverse apophyses Start caudally at the sascrum and move cephalad, so that the first space encoutered is L5 / S1 After this, the upper transverse apophyses are correctly identified Place the probe so that it focus the L2 to L4 transerse apophyses. The acousic shadow is refered as the trident The psoas muscle is assessed through the trident In the psoas muscle, hyperechoic striation correspond to the lumbar plexus. However, given the fibrilar nature of the muscle, one must not jump to conclusions Nerve fibers are usually more oblique, thickned. Placing the probe more latearlly, makes us lose the typical trident appearence, but allows us to identify the quadratus lombarum and the kidney.
and day 7 at 5ºC. Lopez-Galvez et al. 2010 reported that slight off-odours were detected after 10 days of storage but panellists also indicated that samples were acceptable for consumption. In the current study by day 10, both samples stored at temperatures 5ºC and 15ºC presented off-odours but the ultrasound treated sample for 5 min do not reached the acceptability levels. According to PLS, temperature has a slight major influence comparing with storage time. For lettuce, browning is considered to be the critical factor in perceived loss of quality. Cut edge tissue browning and surface browning had similar behaviour during storage. The ultrasound treated samples for 5 min showed the higher values corresponding to lower sensory quality. Samples stored at 15ºC showed browning appearance at a higher rate. The PLS showed that both storage time and temperature influence the decreasing in sensory quality. In works with other decontaminations technologies Lopez-Galvez et al. 2010 is reported that after washing with aqueous chlorine dioxide and sodium hypochlorite no significant changes were notice related to browning. Olmez et al. 2009 stated that above 2.5 ppm ozone levels, there was a loss in colour, freshness and onset of browning, which in turn resulted in a reduction in the shelf-life of product. Sogginess and watery showed high scores from day 0 for the treated samples and the control sample, at both temperatures. PLS shows that storage time explains 82% of the results related to sogginess and watery of the samples. Palma-Salgado et al. 2014 reported no significant differences in sogginess during 14 days of storage for Iceberg or Romaine lettuce, both treated with chlorine and ultrasound. Sogginess and texture represent the crispness that is also an important quality parameter as consumers associate it with the freshness of the product (Kilcast et al. 2000). Related to texture, samples stored at 5ºC showed better quality results than the ones stored at 15ºC. For this parameter, all the samples present very similar scores. The PLS showed that temperature might have slightly major influence than storage time.
Dr. A Govardhan did his Intermediate from APRJC Nagarjuna Sagar, during 1986-1988, BE in Computer Science and Engineering from Osmania University College of Engineering, Hyderabad in 1992, M.Tech from Jawaharlal Nehru University(JNU), Delhi in 1994 and he earned his Ph.D from Jawaharlal Nehru Technological Univesity, Hyderabad in 2003.He is the Director Evaluation JNTU Hyderabad. He guided 10 Ph.D theses, 1 M.Phil and 123 M.Tech projects. He has 152 Research Publications in International/National Journals and Conferences. Dr. Govardhan is a Member in Executive Council, JNTUH, He is a member of Standing Committee for Academic Senate, JNT University Hyderabad and Academic Advisory Committee (AAC), UGC-Academic Staff College and Sports Council, JNT University Hyderabad. He is a Member on the Editorial Boards for Seven International Journals. He had attended an International Conference in Stockholm, Sweden. He is also a member in various Professional and Service- oriented bodies. He had received the best teacher award from Andhra Pradesh Govt. in the year 2011-12. This year he has been a selected for a prestigious “Dr Sarvepally Radhakrishna" NATIONAL Award.
The distribution patterns of crystallographic ori- entation must also reflect the increase in the metamor- phic conditions. Then, the preferred orientations must become stronger from lower to higher temperature lev- els and the crystal plastic processes responsible for the recrystallization of the aggregates must reflect the re- gional deformational conditions. These data, obtained mainly via EBSD once only c-axes distribution patterns can be easily determined using U-stage, are presented in the figure 16, as pole figures. It is clear that the c- axes distribution pattern become more concentrated for the higher metamorphic conditions and it indicates that the metamorphism increases once a Type II crossed gir- dle become an asymmetrical single girdle for the higher temperature levels (Schmid & Casey 1986) (Fig. 16 a, I-II). The distribution patterns identified for the poles of prismatic planes are in agreement with the metamorphic gradient (Fig. 16 b, I-II). In the lower temperature condi- tions, the poles are distributed according to wide girdle, with broad spreading, but the maximum concentration is close to stretching lineation (Fig. 16 b, I). This textural pattern is compatible with the activation of slip system according to basal planes, what is in agreement with the c-axes distribution pattern, whose maxima concentration forms high angle with the rock foliation (Fig. 16 a, I). This is a typical crystal plastic process in low metamor- phic condition (Schmid & Casey 1986, Law et al. 1990, Law 1990, Hirth & Tullis 1992, Stipp et al. 2002). In the higher metamorphic condition the preferred orientations become stronger once the girdle generated for the poles of prisms is better defined (Fig. 16 b, II). The orientation patterns of poles of rhombohedral planes, although show a wide dispersion, become stronger in the domain with higher temperature condition, in agreement with the fur- ther textural data (Fig. 16 c, I-II).