Translational control
Translational control in plant antiviral immunity
... sion of global in vivo translation and decreased loading of host mRNA in actively translating polysomes (PS) frac- tions. Likewise, induction of T474D expression through a dexamethasone-inducible promoter also impairs ...
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Translational control by the DEAD Box RNA helicase belle regulates ecdysone-triggered transcriptional cascades.
... Translational control is a critical mechanism for ensuring proper distribution and subcellular localization of proteins during development ...belle-dependent translational control, we examined ...
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The Drosophila Translational Control Element (TCE) is required for high-level transcription of many genes that are specifically expressed in testes.
... To investigate the importance of core promoter elements for tissue-specific transcription of RNA polymerase II genes, we examined testis-specific transcription in Drosophila melanogaster. Bioinformatic analyses of core ...
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Tunable translational control using site-specific unnatural amino acid incorporation in Escherichia coli
... The translational switch using site-specific IY incorporation can be used as a “tunable translational controller” that regulates the translational efficiency in each individual ...the ...
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miRNA-dependent translational repression in the Drosophila ovary.
... miRNA-dependent translational control does operate in the ovary, then the site or sites at which the regulation occurs will be of interest, and may provide information about possible ...miRNA-dependent ...
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Regulatory BC1 RNA and the fragile X mental retardation protein: convergent functionality in brain.
... local translational repression is vital for a neuron to ensure that proteins are only synthesized when and where ...and translational repression by BC1 RNA and FMRP on the other ...[7,29,46]. ...
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Maternal behavior in basic science: translational research and clinical applicability
... ability to assess circumstances that cannot plausibly be manipulated in humans make these studies more relevant. An overview of the most significant limitations and advantages of the use of animals for ...
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PATACSDB—the database of polyA translational attenuators in coding sequences
... programed translational frameshifts in such mRNA transcripts giving rise to alternative protein products from those ...ultimate control over the production and stability of alternative transcripts from ...
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A success in Toxinology translational research in Brazil: Bridging the gap
... describe translational research as “high risk” and are seldom viewed by their peers as contributing “authentic” knowledge that would bestow symbolic capital in their ...performing translational research ...
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Eliminating the Neglected Tropical Diseases: Translational Science and New Technologies.
... Whether STH infections, schistosomiasis, and onchocerciasis (now targeted by preventive chemotherapy) could be eliminated without new and additional tools has also generated debate. For instance, a recent analysis based ...
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An Acad Bras Cienc (2015) 87 (2 Suppl.)
... Aminoglycosides such as gentamicin, amikacin and tobramycin have important clinical applications in the treatment of serious Gram-negative bacterial infections, and in the experimental treatment of recessive diseases ...
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Translational research in neglected tropical diseases: looking beyond the boundaries!
... Similarly, disciplines such as Biomedical Engineering, Robotics, Applied Mechanics, etc., exist in the Indian Institutes of Technology (IITs); state-of-the art molecular biology research facilities are found for example, ...
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Identification and characterization of HTLV-1 HBZ post-translational modifications.
... Human T-cell leukemia virus type-1 (HTLV-1) is estimated to infect 15–25 million people worldwide, with several areas including southern Japan and the Caribbean basin being endemic. The virus is the etiological agent of ...
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Antipredatory Behavior of Zebrafish: Adaptive Function and a Tool for Translational Research
... (i.e., translational relevance) is if one ignores these species-specific characteristics, we (Gerlai, 2001, 2002; Gerlai and Clayton, 1999) and others (Blanchard, Griebel, and Blanchard, 2003 and references ...
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Dynamical consequences of bandpass feedback loops in a bacterial phosphorelay.
... Here we assume that protein degradation is negligible compared to protein dilution. Hence, c~1=hr, similar to the rates of dilution by cell growth observed experimentally. This degradation term is Figure 2. Phosphorelay ...
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Differences in eotaxin serum levels patients with recent onset and in chronic stable schizophrenia : a clue for understanding accelerating aging profile
... for Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil Programa de Pós-Graduação em Medicina: Psiquiatria, Universidade Federal do Rio ...
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CRISPR/Cas9‐mediated genome editing: from basic research to translational medicine
... The recent development of the CRISPR/Cas9 system as an efficient and accessi- ble programmable genome-editing tool has revolutionized basic science research. CRISPR/Cas9 system-based technologies have armed researchers ...
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Abnormal Motor Activity and Thermoregulation in a Schizophrenia Rat Model for Translational Science.
... are available about the BT changes in schizophrenia animal models measured in unrestrained condition. We observed that in spite of the significantly lower activity during both phases in the new substrain; these animals ...
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Cloning and Functional Assessment of the Recombinant Human Hepcidin-25 in the Baculovirus Expression System
... translational modification in the bacterial expression system (Carvalho et al. 2012), differences in glycosylation encountered in the yeast expression system (high mannose) (Durocher and Butler 2009), and the high ...
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Scanning MscL Channels with Targeted Post-Translational Modifications for Functional Alterations.
... The cytoplasmic region of MscL at the lipid-cytoplasmic interphase has been proposed to enter a more hydrophobic environment to accommodate for the tilting of TM2 while channel gating [14, 23]. We have proposed that a ...
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